Daniel J W, Babcock K
J Bacteriol. 1966 Oct;92(4):1028-35. doi: 10.1128/jb.92.4.1028-1035.1966.
Daniel, John W. (University of Wisconsin, Madison), and Karlee Babcock. Methionine metabolism of the myxomycete Physarum polycephalum. J. Bacteriol. 92:1028-1035. 1966.-Previous studies have shown that Physarum polycephalum requires exogenous methionine for growth, but not cysteine, folic acid, or vitamin B(12). Methionine can also serve as the sole source of sulfur for all cellular requirements, without limiting the growth rate. S-methyl-l-cysteine, 2-hydroxy-4-methiol butyric acid, S-adenosyl-l-methionine, and methionine peptides were the only compounds supporting growth, when substituted for methionine. Other methionine analogues, methyl donors in combination with homocysteine, and intermediates of the cystathionine pathway were not active. Ethionine and S-ethyl cysteine were good methionine antagonists. This myxomycete is apparently unable to synthesize the methyl or S-methyl group, although it still appears able to transmethylate, at least from S-methyl cysteine, and probably from S-adenosyl methionine, which can also serve as a source of adenine.
丹尼尔，约翰·W.（威斯康星大学麦迪逊分校）和卡莉·巴布科克。多头绒泡菌的蛋氨酸代谢。《细菌学杂志》92:1028 - 1035。1966年。——先前的研究表明，多头绒泡菌生长需要外源性蛋氨酸，但不需要半胱氨酸、叶酸或维生素B12。蛋氨酸还可以作为所有细胞需求的唯一硫源，而不限制生长速率。当替代蛋氨酸时，S - 甲基 - L - 半胱氨酸、2 - 羟基 - 4 - 甲硫基丁酸、S - 腺苷 - L - 蛋氨酸和蛋氨酸肽是仅有的支持生长的化合物。其他蛋氨酸类似物、与同型半胱氨酸结合的甲基供体以及胱硫醚途径的中间体均无活性。乙硫氨酸和S - 乙基半胱氨酸是良好的蛋氨酸拮抗剂。这种黏菌显然无法合成甲基或S - 甲基基团，尽管它似乎仍然能够进行转甲基作用，至少可以从S - 甲基半胱氨酸进行转甲基，可能也能从S - 腺苷甲硫氨酸进行转甲基，而S - 腺苷甲硫氨酸还可以作为腺嘌呤的来源。
