Judge D M, Dickman P S, Trapukdi S
Am J Clin Pathol. 1976 Jul;66(1):40-5. doi: 10.1093/ajcp/66.1.40.
This report documents a foregut endocrine neoplasm in an unusual location, the main hepatic bile duct, and describes simplified methods of detecting similar endocrine tumors. Formaldehyde fume-induced fluorescence (FIF) is a quick, specific method to demonstrate biogenic amines. FIF combined with histochemical procedures showing abundant alpha-glycerol phosphate dehydrogenase and esterases indicates the neural crest origin of these and related neoplasms. Amine precursor uptake and decarboxylation (APUD) is a significant marker of these cells and gives them their name.
本报告记录了一例发生于非寻常部位——肝主胆管的前肠内分泌肿瘤，并描述了检测类似内分泌肿瘤的简化方法。甲醛烟雾诱导荧光法（FIF）是一种快速、特异的显示生物胺的方法。FIF 与显示丰富α-甘油磷酸脱氢酶和酯酶的组织化学方法相结合，表明这些肿瘤及相关肿瘤起源于神经嵴。胺前体摄取和脱羧作用（APUD）是这些细胞的一个重要标志物，也是它们名称的由来。
