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[己醛和硫喷妥钠麻醉对不同脑区能量代谢的影响]

[Effect of hexenal and thiopental anesthesia on energy metabolism in different brain areas].

作者信息

Batrak G E, Nerush P A

出版信息

Vopr Med Khim. 1977 Nov-Dec(6):745-8.

PMID:595482
Abstract

Respiration and oxidative phosphorylation were studied in dog mitochondria of visua and acoustic areas of brain cortex as well as of medial thalamus after hexenal and thiopental narcosis. The distinct increase in the respiratory activity, which was not accompanied by phosphate esterification, was observed in mitochondria of medial thalamus as compared with the organelles of brain cortex from visual and acoustic areas. The phenomenon was responsible for uncoupling of respiration and phosphorylation processes.

摘要

在己烯醛和硫喷妥麻醉后,对犬大脑皮层视觉和听觉区域以及内侧丘脑的线粒体呼吸作用和氧化磷酸化进行了研究。与视觉和听觉区域大脑皮层的细胞器相比,内侧丘脑线粒体的呼吸活性明显增加,且不伴有磷酸酯化作用。该现象导致了呼吸作用和磷酸化过程的解偶联。

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