Batrak G E, Nerush P A
Farmakol Toksikol. 1975 Sep-Oct;38(5):527-31.
Experiments conducted on 50 puppies of 2-days, 2-weeks and a month old evidenced that the maturing of the central nervous system in puppies was accompanied by a progressive growth of the bioelectric activity and of the energy exchange forse. With advancing age of the animals the inhibitory action of ether on the oxygen uptake by the tissues of the visual, auditory cortical zones and of the medial thalamus along with the biocurrents in these structures were on a decline. At the same time, as the post-natal development of the animals went on, the processes of oxidative phosphorylation in the cortical segments were disturbed greater than at the 2-week age. In 2-day old animals it did not change substantially by comparison with controls.
对50只2日龄、2周龄和1月龄幼犬进行的实验表明,幼犬中枢神经系统的成熟伴随着生物电活动和能量交换的逐渐增长。随着动物年龄的增长,乙醚对视觉、听觉皮质区和内侧丘脑组织的氧摄取以及这些结构中的生物电流的抑制作用逐渐减弱。与此同时,随着动物出生后的发育,皮质段的氧化磷酸化过程比2周龄时受到的干扰更大。与对照组相比,2日龄动物的氧化磷酸化过程没有显著变化。