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[红细胞生成刺激过程中大鼠肾脏亚细胞组分的促红细胞生成素形成及酯酶活性]

[Erythropoietin-forming and esterase activity of rat kidney subcellular fractions during stimulation of erythropoiesis].

作者信息

Novikov N M, Voronkov S F, Voloshchenko L G, Mikhaĭlova S N

出版信息

Vopr Med Khim. 1977 Nov-Dec(6):756-9.

PMID:595483
Abstract

Stimulation of erythropoiesis in rats (hemolytic-phenylhydrazine and acute posthemorrhagic anemia, effect of hypoxic hypoxia) was accompanied by an increased erythropoietine-formating activity in kidney microsomes and light mitochondria. The phenomenon correlated with an increased esterase activity in hypotonic supernatant of kidney homogenate mainly due to the enzymatic fraction, corresponding to alpha2-globulin by its mobility. Histochemical examination of kidney showed that the most distinct alterations in the esterase activity were observed in epithelial cells of nephron proximal part and in capillary endothelium.

摘要

大鼠红细胞生成的刺激(溶血-苯肼和急性失血性贫血,低氧性缺氧的影响)伴随着肾微粒体和轻线粒体中促红细胞生成素形成活性的增加。该现象与肾匀浆低渗上清液中酯酶活性增加相关,这主要归因于酶组分,其迁移率与α2球蛋白相对应。肾脏的组织化学检查表明,在肾单位近端部分的上皮细胞和毛细血管内皮中观察到酯酶活性最明显的变化。

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[Erythropoietin-forming and esterase activity of rat kidney subcellular fractions during stimulation of erythropoiesis].[红细胞生成刺激过程中大鼠肾脏亚细胞组分的促红细胞生成素形成及酯酶活性]
Vopr Med Khim. 1977 Nov-Dec(6):756-9.
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