[化学致癌作用早期大鼠肝脏单加氧酶系统的动力学参数]
[Kinetic parameters of the rat liver monooxygenase system in the early stages of chemical carcinogenesis].
作者信息
Rivkind N B, Tsyrlov I B, Gromova O A, Liakhovich V V
出版信息
Vopr Med Khim. 1977 Nov-Dec(6):774-7.
PMID:595484
Abstract
Functions of the liver monooxygenase system, participating in metabolism of 3,4-benzpyrene, were shown to vary significantly at different steps of carcinogenesis induced by 3,4-benzpyrene. These variations appear to be due to changes in the effect of monooxygenase-epoxide hydrase complex in rat liver microsomes.
摘要
肝脏单加氧酶系统参与3,4-苯并芘代谢的功能，在3,4-苯并芘诱导的致癌作用的不同阶段有显著变化。这些变化似乎是由于大鼠肝微粒体中单加氧酶-环氧化物水合酶复合物作用的改变所致。
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