Rozanov A Ia, Kirilenko O A, Savchenko S N, Stepanova L N, Agafonova N E
Vopr Med Khim. 1977 Sep-Oct;23(5):661-7.
Pantothenate, penetrating the liver tissue after intraperitoneal administration into young rats at a dose 100 mumole/kg was metabolized to unidentified substances within 15-30 min without accumulation of 4-phosphopantothenate. Within subsequent 2-4 hrs period pantothenate, 4-phosphopantothenate, CoA and considerably higher amounts of the unidentified metabolites (apparently symmetric and mixed (disulphides) were simultaneously accumulated in liver tissue; the latter substances determined the subsequent prolonged and essential elevation in content of CoA in the liver tissue. The phase dynamics of accumulation in liver tissue of the administered pantothenate is due to its recirculation from intestine and to alteration in the activity of pantothenate metabolizing enzymes, particularly those, which catalyze the reactions of thiodisulphide metabolism.
泛酸盐以100微摩尔/千克的剂量腹腔注射给幼鼠后，穿透肝脏组织，在15 - 30分钟内代谢为未知物质，未积累4 - 磷酸泛酸盐。在随后的2 - 4小时内，泛酸盐、4 - 磷酸泛酸盐、辅酶A以及大量未知代谢物（显然是对称的和混合的（二硫化物））同时在肝脏组织中积累；后一种物质决定了肝脏组织中辅酶A含量随后的长期且显著升高。肝脏组织中所给予泛酸盐积累的阶段动态是由于其从肠道再循环以及泛酸盐代谢酶活性的改变，特别是那些催化硫代二硫化物代谢反应的酶。
