Nagel M, Reissmann K, Trenckmann H
Z Gesamte Inn Med. 1977 Aug 15;32(16):389-92.
It is reported on the results of determinations of the antistreptolysin titre in patients with infectious hepatitis, renal and essential hypertension, mitral stenosis, acute tonsillitis, scarlet fever, rheumatic fever as well as rheumatoid arthritis according to the usual and the dextran sulphate absorption method in altogether 739 patients. Here as in a former publication in 1,700 normal persons partly considerable significant differences between the antistreptolysin titre with and without dextran sulphate were found. The two techniques are discussed, also the influence of the beta-lipoproteins with their proportion of phosphatide on the result of the antistreptolysin titre. It is possible to absorb beta-lipoproteins and perhaps also phosphatides with the help of the addition of dextran sulphate. The present investigations show unequivocally that the absorption the dextran sulphate is a necessary demand which saves the clinician from diagnostic and therapeutic errors. The antistreptolysin reaction is to be regarded only as one constituent for the clinical diagnosis and must not be overvalued in its importance.
本文报道了采用常规方法和硫酸葡聚糖吸附法对739例传染性肝炎、肾性和原发性高血压、二尖瓣狭窄、急性扁桃体炎、猩红热、风湿热以及类风湿性关节炎患者进行抗链球菌溶血素滴度测定的结果。与之前对1700名正常人的研究结果一样，发现使用和不使用硫酸葡聚糖时抗链球菌溶血素滴度存在部分显著差异。文中讨论了这两种技术，以及β-脂蛋白及其磷脂比例对抗链球菌溶血素滴度结果的影响。借助添加硫酸葡聚糖可以吸附β-脂蛋白，或许还能吸附磷脂。目前的研究明确表明，硫酸葡聚糖吸附是一项必要要求，可使临床医生避免诊断和治疗错误。抗链球菌溶血素反应仅应被视为临床诊断的一个组成部分，其重要性不应被高估。
