Reissmann M, Reissmann K, Trenckmann H
Z Gesamte Inn Med. 1975 Aug 15;30(16):527-8.
1,700 blood samples of healthy test persons without clinically and paraclinically provable streptococcal diseases were examined for their content of antistreptolysin. Beside the usual method parallel determinations were carried out after addition of dextran sulfate. Thus increases of unspecific antistreptolysin titres shall be in most cases excluded, above all by the influence of the lipoproteins. The absorption of dextran sulfate led to the decrease of the antistreptolysin titre by 12.33%. Furthermore could be proved that the average antistreptolysin titre of female test persons is ca. 20 antistreptolysin units below the titre of male test persons, that seasonal variations of the antistreptolysin titre with the highest titres appear in the first and third quarter which may be explained by a bad unspecific defensive condition, that, furthermore, the antistreptolysin titres increase to the 14th year and then continuously decrease and that in new-born children the arithmetic mean value of the antistreptolysin units is significantly higher than in their mothers. Hereby an active influence of the placenta on the transmission of antibodies seems to be possible. Though a slightly increased financial expenditure is necessary for dextran sulfate, temporarily and concerning working technique, however, no larger loads appear, it is justifiable to perform the determination of antistreptolysin titres only by means of dextran sulfate-absorbed sera, since in this way a considerable number of unspecific and misleading reactions can be excluded.
对1700份无临床和副临床可证实的链球菌疾病的健康受试者血样进行抗链球菌溶血素含量检测。除常规方法外，还在添加硫酸葡聚糖后进行了平行测定。这样，在大多数情况下可以排除非特异性抗链球菌溶血素滴度的升高，尤其是受脂蛋白的影响。硫酸葡聚糖的吸收导致抗链球菌溶血素滴度降低了12.33%。此外，还可以证明女性受试者的平均抗链球菌溶血素滴度比男性受试者的滴度低约20个抗链球菌溶血素单位；抗链球菌溶血素滴度的季节性变化在第一和第三季度最高，这可能是由于非特异性防御状态不佳所致；此外，抗链球菌溶血素滴度在14岁时升高，然后持续下降；新生儿的抗链球菌溶血素单位算术平均值明显高于其母亲。由此看来，胎盘对抗体传递可能有积极影响。虽然使用硫酸葡聚糖会暂时增加一些费用，并且在操作技术方面也有一定要求，但不会造成太大负担，仅通过硫酸葡聚糖吸收血清来测定抗链球菌溶血素滴度是合理的，因为这样可以排除大量非特异性和误导性反应。
