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1
Liver necrosis from paracetamol.对乙酰氨基酚所致肝坏死
Br J Pharmacol Chemother. 1966 Mar;26(3):606-14. doi: 10.1111/j.1476-5381.1966.tb01841.x.
2
Hepatotoxicity of phenacetin and paracetamol in the Gunn rat.非那西丁和对乙酰氨基酚对冈恩大鼠的肝毒性
Pathology. 1981 Oct;13(4):757-62. doi: 10.3109/00313028109086649.
3
Decreased toxicity of the N-methyl analogs of acetaminophen and phenacetin.对乙酰氨基酚和非那西丁的N-甲基类似物毒性降低。
Res Commun Chem Pathol Pharmacol. 1978 Oct;22(1):61-71.
4
Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilate: oxygenation or electron transfer?对乙酰氨基酚及其衍生物非那西丁和贝诺酯的肝毒性代谢活化：氧化作用还是电子转移？
Biochem Pharmacol. 1981 Mar 1;30(5):399-402. doi: 10.1016/0006-2952(81)90622-5.
5
Proceedings: Hepatotoxicity and metabolism of paracetamol in rats and mice.论文集：对乙酰氨基酚在大鼠和小鼠中的肝毒性及代谢
Naunyn Schmiedebergs Arch Pharmacol. 1974;282(Suppl):suppl 282:R93.
6
Drug metabolism in the production of liver injury.
Med Clin North Am. 1975 Jul;59(4):877-85. doi: 10.1016/s0025-7125(16)31986-1.
7
General and renal toxicity of phenacetin, paracetamol and some anti-mitotic agents in the rat.非那西丁、对乙酰氨基酚及某些抗有丝分裂剂对大鼠的全身毒性和肾毒性
Arch Toxikol. 1972;28(4):225-69. doi: 10.1007/BF00330059.
8
Letter: Treatment of acute paracetamol hepatotoxicity.信件：对乙酰氨基酚急性肝毒性的治疗
Lancet. 1973 Dec 15;2(7842):1387. doi: 10.1016/s0140-6736(73)93350-3.
9
Amphibian organ culture in experimental toxicology: the effects of paracetamol and phenacetin on cultured tissues from urodele and anuran amphibians.
Toxicology. 1982;25(1):31-40. doi: 10.1016/0300-483x(82)90082-8.
10
Serum transaminase levels after experimental paracetamol-induced hepatic necrosis.实验性对乙酰氨基酚诱导的肝坏死后的血清转氨酶水平
Gut. 1975 Oct;16(10):800-7. doi: 10.1136/gut.16.10.800.

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J Evid Based Integr Med. 2024 Jan-Dec;29:2515690X241263063. doi: 10.1177/2515690X241263063.
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The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review.用于人类对乙酰氨基酚/扑热息痛所致肝损伤的循环生物标志物的演变：一项范围综述
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Sex-specific neurobehavioral and prefrontal cortex gene expression alterations following developmental acetaminophen exposure in mice.发育期暴露于对乙酰氨基酚会导致雌雄小鼠神经行为学和前额叶皮质基因表达出现性别特异性改变。
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Lab Anim Res. 2019 Sep 3;35:16. doi: 10.1186/s42826-019-0017-x. eCollection 2019.
9
Testing of acetaminophen in support of the international multilaboratory in vivo rat Pig-a assay validation trial.支持国际多实验室体内大鼠 Pig-a 检测验证试验的对乙酰氨基酚检测。
Environ Mol Mutagen. 2020 Jun;61(5):508-525. doi: 10.1002/em.22368. Epub 2020 Apr 15.
10
JNK Signaling Pathway Mediates Acetaminophen-Induced Hepatotoxicity Accompanied by Changes of Glutathione S-Transferase A1 Content and Expression.JNK信号通路介导对乙酰氨基酚诱导的肝毒性，并伴有谷胱甘肽S-转移酶A1含量和表达的变化。
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本文引用的文献

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THE ACUTE TOXICITY OF TANNIC ACID ADMINISTERED INTRAGASTRICALLY.经胃内给予鞣酸的急性毒性
Can Med Assoc J. 1965 Jun 19;92(25):1292-7.
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THE COMPARATIVE PHARMACOLOGY.
Appl Ther. 1963 Nov;5:963-9.
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Postmortem shifts in the weight and water levels of body organs.死后身体器官重量和含水量的变化。
Toxicol Appl Pharmacol. 1963 Jan;5:119-28. doi: 10.1016/0041-008x(63)90086-3.
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Determination of blood and other tissue concentrations of paracetamol in dog and man.
J Pharm Pharmacol. 1963 Jul;15:440-4. doi: 10.1111/j.2042-7158.1963.tb12811.x.
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Dilution of dose and acute oral toxicity.
Toxicol Appl Pharmacol. 1962 Nov;4:759-62. doi: 10.1016/0041-008x(62)90106-0.
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The acute oral toxicity in guinea pigs of acetylsalicylic acid, phenacetin, and caffeine, alone and combined.
Toxicol Appl Pharmacol. 1960 Jan;2:23-32. doi: 10.1016/0041-008x(60)90067-3.
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The acute oral toxicity of phenacetin.非那西丁的急性经口毒性。
Toxicol Appl Pharmacol. 1959 May;1(3):240-9. doi: 10.1016/0041-008x(59)90108-5.
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Gastrointestinal pharmacology of antipyretic-analgetic agents. II. Absorption and smooth muscle effects.
Arch Int Pharmacodyn Ther. 1959 Apr 1;119(3-4):398-408.
9
[Pharmacodynamic properties of the N-acetyl-para-aminophenol, metabolite of phenacetin and the acetanilide].[非那西丁和乙酰苯胺的代谢产物N-乙酰对氨基酚的药效学特性]
Therapie. 1956;11(2):300-7.
10
N-acetyl-p-aminophenol (tylenol elixir) as a pediatric antipyretic-analgesic.对乙酰氨基酚（泰诺林酏剂）作为儿科退烧药和镇痛药。
J Am Med Assoc. 1956 Apr 7;160(14):1219-21. doi: 10.1001/jama.1956.02960490033009.

Liver necrosis from paracetamol.

作者信息

Boyd E M, Bereczky G M

出版信息

Br J Pharmacol Chemother. 1966 Mar;26(3):606-14. doi: 10.1111/j.1476-5381.1966.tb01841.x.

DOI:10.1111/j.1476-5381.1966.tb01841.x
PMID:5959211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1510721/
Abstract
摘要