经胃内给予鞣酸的急性毒性
THE ACUTE TOXICITY OF TANNIC ACID ADMINISTERED INTRAGASTRICALLY.
作者信息
BOYD E M, BERECZKY K, GODI I
出版信息
Can Med Assoc J. 1965 Jun 19;92(25):1292-7.
Abstract
The LD(50) +/- S.E. of tannic acid given orally to albino rats was found to be 2.26+/-0.083 g. per kg. body weight, which is higher than its apparent LD(50) when given per rectum. The immediate cause of death was respiratory failure preceded by convulsions when death occurred early and by hypothermic cachexia when death was delayed. Death was associated with a progressively developing hepatic necrosis and nephritis and a temporary acute gastroenteritis. It was accompanied by loss of weight and edema in many organs, evidence of stimulation of the spleen, adrenal cortex and testes, and atrophy of the thymus. Recovery in survivors was associated with a temporary increase in weight of the spleen and testes and persistence of loss of weight in the adrenal, pyloric stomach, and skin.
摘要
经口给予白化大鼠单宁酸的半数致死量（LD(50)）±标准误为每千克体重2.26±0.083克，这高于经直肠给药时的表观半数致死量。死亡的直接原因是呼吸衰竭，若早期死亡则先出现惊厥，若死亡延迟则出现体温过低性恶病质。死亡与进行性发展的肝坏死、肾炎以及暂时性急性肠胃炎相关。它还伴有体重减轻和许多器官水肿，脾脏、肾上腺皮质和睾丸有受刺激的迹象，胸腺萎缩。存活者的恢复与脾脏和睾丸重量暂时增加以及肾上腺、幽门部胃和皮肤持续体重减轻有关。
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