Bunin K V, Firsanov V I, Kravtsov E G, Shchukin P I
Zh Mikrobiol Epidemiol Immunobiol. 1977 Sep(9):49-53.
The authors carried out a comparative analysis of the changes in the antibody synthesis and their immunological maturation in the immunization with various doses of the Vi-antigen of linear rats differing by the capacity to deposit this antigen. August rats with a high capacity to deposit the Vi-antigen (in comparison with Wistar rats in which this capacity was less) were characterized by an increased level of highly avid antibodies. The interlinear differences were found in the character of the changes in the antibody synthesis depending on the immunizing dose of the antigen. Genotypical peculiarities of the immunological maturation of the antibodies were demonstrated. The authors suppose that the described phenomenon was genetically determined and referred to the factors determining the individual immunological reactivity. In the choice of the optimal immunizing doses of the antigens the authors recommend complex determination of the antibody level and the degree of their avidity.
作者对不同线性大鼠在接种不同剂量Vi抗原时抗体合成及其免疫成熟的变化进行了比较分析，这些大鼠沉积该抗原的能力不同。与Wistar大鼠（其沉积Vi抗原的能力较低）相比，具有高沉积Vi抗原能力的奥古斯特大鼠的特点是高亲和力抗体水平升高。根据抗原的免疫剂量，发现不同品系大鼠在抗体合成变化特征方面存在差异。证明了抗体免疫成熟的基因型特性。作者推测所描述的现象是由基因决定的，并且与决定个体免疫反应性的因素有关。在选择抗原的最佳免疫剂量时，作者建议综合测定抗体水平及其亲和力程度。
