河豚毒素对龙虾大神经轴突钠电导增加的阻断作用。
Blockage of sodium conductance increase in lobster giant axon by tarichatoxin (tetrodotoxin).
作者信息
Takata M, Moore J W, Kao C Y, Fuhrman F A
出版信息
J Gen Physiol. 1966 May;49(5):977-88. doi: 10.1085/jgp.49.5.977.
Abstract
Tarichatoxin, isolated from California newt eggs, has been found to selectively block the increase of sodium conductance associated with excitation in lobster giant axons at nanomolar concentrations. This resulted from a reduction in the amplitude of the conductance increase rather than a change in its temporal characteristics. The normal potassium conductance increase with depolarization is not altered. A high concentration of calcium applied concomitantly with the toxin significantly improves the reversibility of the sodium blocking. This toxin has recently been identified as chemically identical with tetrodotoxin from the puffer fish. Toxins from the two sources are equally effective and are shown to have an action which is distinctly different from that of procaine.
摘要
从加州蝾螈卵中分离出的河豚毒素，已发现在纳摩尔浓度下能选择性地阻断龙虾巨轴突兴奋时伴随的钠电导增加。这是由于电导增加幅度的降低，而非其时间特性的改变。正常情况下，随着去极化而增加的钾电导并未改变。与毒素同时施加高浓度的钙可显著提高钠阻断的可逆性。这种毒素最近被鉴定为在化学上与河豚鱼中的河豚毒素相同。来自这两种来源的毒素效果相同，且显示出与普鲁卡因明显不同的作用。
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TETRODOTOXIN BLOCKAGE OF SODIUM CONDUCTANCE INCREASE IN LOBSTER GIANT AXONS.河豚毒素对龙虾巨轴突中钠电导增加的阻断作用
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