Jacobsen K
Acta Orthop Scand. 1977;48(5):520-6. doi: 10.3109/17453677708989742.
Based on a series of 48 patients with old untreated ruptures of one or both cruciate ligaments, the development of osteoarthrotic changes was demonstrated by radiography and at operation. The changes were similar to those seen in animal experiments and developed in the same sequence. Osteophytes occurred in knees with anterior cruciate insufficiency after about 2 years; significant osteoarthrotic changes occurred after longer periods, and particularly in knees with damage to both cruciate ligaments.
基于对48例单侧或双侧交叉韧带陈旧性未治疗断裂患者的系列研究，通过X线摄影和手术证实了骨关节炎改变的发展情况。这些改变与动物实验中观察到的相似，且发展顺序相同。骨赘在大约2年后出现在前交叉韧带功能不全的膝关节中；较长时间后出现明显的骨关节炎改变，尤其是在双侧交叉韧带受损的膝关节中。
