麻醉药品、酒精和巴比妥类药物对下丘脑-垂体-性腺轴影响的比较分析。

A comparative analysis of the effects of narcotics, alcohol and the barbiturates on the hypothalamic-pituitary-gonadal axis.

作者信息

Cicero T J, Badger T M

出版信息

Adv Exp Med Biol. 1977;85B:95-115. doi: 10.1007/978-1-4615-9038-5_8.

Abstract

The purpose of this paper is to provide an overview of our current state of knowledge regarding the effects of alcohol, the narcotics and the barbiturates on the hypothalamic-pituitary-gonadal axis in the male. Three facets of this problem will be considered: acute drug effects; chronic effects, particularly with respect to the development of tolerance and physical dependence; and, finally, an attempt will be made to indicate the way in which these three substances of abuse are similar and/or dissimilar in their effects on this system. The effects of acute and chronic treatment with narcotics, alcohol and the barbiturates will be discussed first and then an attempt will be made, in a General Discussion, to summarize the data, make general comparisons between the drugs and suggest future lines of research.

摘要

本文旨在概述我们目前对于酒精、麻醉药品和巴比妥类药物对男性下丘脑 - 垂体 - 性腺轴影响的认识状况。将考虑该问题的三个方面：药物的急性效应；慢性效应，特别是关于耐受性和身体依赖性的发展；最后，将尝试指出这三种滥用物质在对该系统的影响方面的异同之处。将首先讨论麻醉药品、酒精和巴比妥类药物急性和慢性治疗的效应，然后在“一般性讨论”中尝试总结数据，对这些药物进行总体比较，并提出未来的研究方向。