Lie O
Acta Vet Scand. 1977;18(4):572-4. doi: 10.1186/BF03548424.
Considerable evidence for the existence of a direct genetic control of the immune response has been presented during recent years. Experimental work with rodents are the main basis for this evidence. The first study on genetic variations in the antibody response was carried out by (1938). Later (1960) published detailed considerations about the specificity and inheritance of the antibody response. In mice it has been demonstrated that a few dominant immune response (Ir) genes determine the ability to produce antibodies against certain specific antigens ( 1968). The magnitude of the response is probably under the influence of polygenes, which are not associated with Ir genes. This theory is supported by selection for high and low antibody production in mice ( 1972).
近年来，已有大量证据表明免疫反应存在直接的遗传控制。对啮齿动物的实验研究是这一证据的主要依据。关于抗体反应中基因变异的第一项研究是由（1938年）进行的。后来（1960年）发表了关于抗体反应的特异性和遗传性的详细论述。在小鼠中已证明，少数显性免疫反应（Ir）基因决定了产生针对某些特定抗原的抗体的能力（1968年）。反应的强度可能受多基因的影响，这些多基因与Ir基因无关。对小鼠高、低抗体产生进行选择的实验支持了这一理论（1972年）。
