Smith D, Young W W
Am J Hosp Pharm. 1977 Dec;34(12):1347-9.
A study was conducted to determine if high doses of ascorbic acid would affect the two-drop Clinitest determination for glucosuria in normal individuals. Numerous secondary literature sources indicate that large doses of ascorbic acid may cause a false positive Clinitest result. Three-gram and nine-gram doses of ascorbic acid following two dosing schedules (once daily and three times daily) were taken by nine normal individuals to determine if the renal excretion of large enough quantities of ascorbic acid or its metabolites would produce false positive results with the two-drop Clinitest procedure. Each dose was given for seven days in each schedule. There were only two (0.27%) trace positive Clinitest determinations reported out of 748 Clinitest determinations. High doses of ascorbic acid in normal individuals do not appear to affect the two-drop Clinitest determination for urinary glucose. The study indicates a need to be cautious about secondary literature references on drug-laboratory test interferences.
开展了一项研究，以确定高剂量的抗坏血酸是否会影响正常个体尿糖的两滴尿糖定性试验（Clinitest）测定结果。大量的二手文献资料表明，大剂量的抗坏血酸可能会导致尿糖定性试验结果出现假阳性。9名正常个体按照两种给药方案（每日1次和每日3次）服用了3克和9克剂量的抗坏血酸，以确定大量抗坏血酸或其代谢产物经肾脏排泄是否会导致两滴尿糖定性试验法产生假阳性结果。每种给药方案中，每种剂量均服用7天。在748次尿糖定性试验测定中，仅报告了2次（0.27%）微量阳性尿糖定性试验结果。正常个体服用高剂量抗坏血酸似乎不会影响尿糖的两滴尿糖定性试验测定结果。该研究表明，对于药物与实验室检测干扰方面的二手文献参考需要谨慎对待。
