Parker W A, MacCara M E
Am J Hosp Pharm. 1984 Jan;41(1):125-8.
The effect of newer penicillins (azlocillin, mezlocillin, cyclacillin, and piperacillin) a 6 beta-amidinopenicillanic acid derivative (amdinocillin), and newer aminoglycosides (netilmicin and sisomicin) on the accuracy of tests for glycosuria was studied. Solutions of each of the drugs were prepared in urine in a range of clinically obtainable drug concentrations. In addition, urine solutions were prepared that contained the same drug concentrations and 0.5, 1, and 2% glucose. All solutions were tested in triplicate using the five-drop Clinitest method and two glucose oxidase methods (Diastix and Tes-Tape). Falsely elevated Clinitest readings of approximately 0.25% were obtained with the penicillins. These readings were influenced by the concentration of the penicillins and of glucose. Neither amdinocillin nor the aminoglycosides had an effect on Clinitest determinations. None of the drugs interfered with Diastix or Tes-Tape readings. Because the Clinitest-penicillin interaction is unpredictable, Clinitest results should be rechecked using one of the qualitative glucose oxidase tests when Clinitest is used as a quantitative test for glycosuria in patients receiving penicillins. All three tests studied can be used to test for glycosuria in patients receiving amdinocillin or one of the aminoglycosides.
研究了新型青霉素（阿洛西林、美洛西林、环青霉素和哌拉西林）、一种6β-脒基青霉烷酸衍生物（氨比西林）以及新型氨基糖苷类药物（奈替米星和西索米星）对糖尿检测准确性的影响。在一系列临床可获得的药物浓度下，将每种药物溶解于尿液中制成溶液。此外，还制备了含有相同药物浓度以及0.5%、1%和2%葡萄糖的尿液溶液。所有溶液均采用五滴Clinitest法和两种葡萄糖氧化酶法（尿糖试纸和 Tes-Tape）进行一式三份检测。使用青霉素时，Clinitest读数会出现约0.25%的假性升高。这些读数受青霉素浓度和葡萄糖浓度的影响。氨比西林和氨基糖苷类药物均对Clinitest测定无影响。所有药物均不干扰尿糖试纸或Tes-Tape读数。由于Clinitest与青霉素之间的相互作用无法预测，因此当在接受青霉素治疗的患者中使用Clinitest作为糖尿定量检测时，应使用定性葡萄糖氧化酶检测之一重新检查Clinitest结果。所研究的三种检测方法均可用于检测接受氨比西林或其中一种氨基糖苷类药物治疗的患者的糖尿情况。
