Miglietta O
Am J Phys Med. 1977 Dec;56(6):293-9.
The force of contraction of the adductor pollicis before and after dantrolene sodium was evaluated in 5 paraplegic patients. The muscle was indirectly stimulated through supramaximal stimulation of the ulnar nerve at the wrist, with single pulse and variable number of stimuli at frequency of 50 Hz. There was a marked and significant reduction (an average of 64%) of the single twitch response in all patients while on medication. When the muscle, however, was stimulated with tetanic frequency no significant difference was evident in the force of the sustained contraction with or without medication. The amplitude of evoked electrical potentials, simultaneously recorded from the adductor pollicis remained unchanged irrespective of the status of medication. Decrement of the twitch response, with no effect on the electrical activity, tends to substantiate the distal effects of dantrolene on muscle contraction. The drug, however, does not seem to prevent the muscle from achieving its normal maximal tetanic force when activated with frequencies close to the physiological frequencies of maximal, voluntary effort (50 Hz.) These effects point to the usefulness and limitations of the drug in clinical situations.
在5名截瘫患者中评估了丹曲林钠用药前后拇收肌的收缩力。通过对腕部尺神经进行超强刺激间接刺激肌肉，采用单脉冲和频率为50Hz的不同刺激次数。所有患者在用药期间单收缩反应均有显著且明显的降低（平均降低64%）。然而，当以强直频率刺激肌肉时，用药与否在持续收缩力方面并无明显差异。从拇收肌同时记录的诱发电位幅度，无论用药状态如何均保持不变。单收缩反应的减弱，而对电活动无影响，这倾向于证实丹曲林对肌肉收缩的远端效应。然而，当以接近最大自主用力的生理频率（50Hz）激活肌肉时，该药物似乎并不妨碍肌肉达到其正常的最大强直力。这些效应表明了该药物在临床情况下的有用性和局限性。
