水杨酸盐对L-（U-14C）亮氨酸在体外掺入大鼠组织制剂蛋白质中的抑制作用。
Inhibitory effect of salicylate on the incorporation of L-(U-14C)leucine into the protein of rat tissue preparations in vitro.
作者信息
Dawkins P D, Gould B J, Smith M J
出版信息
Biochem J. 1966 Jun;99(3):703-7. doi: 10.1042/bj0990703.
Abstract
- The inhibitory effect of salicylate, in concentrations ranging from 0.1 to 20mm, on the incorporation of radioactivity from l-[U-(14)C]leucine into the protein of isolated rat diaphragm muscle and of cell-free systems from rat liver was studied. 2. The lowest salicylate concentrations producing significant inhibitions of amino acid incorporation were as follows: isolated rat diaphragm, 0.1mm; rat-liver mitochondrial-microsomal system, 0.1mm; rat-liver microsomal system, 0.3mm. 3. Salicylate concentrations of 2.5mm and above were found to inhibit creatine-kinase activity in vitro.
摘要
- 研究了浓度范围为0.1至20毫摩尔的水杨酸盐对L-[U-(14)C]亮氨酸的放射性掺入分离的大鼠膈肌肌肉蛋白以及大鼠肝脏无细胞体系的抑制作用。2. 产生显著氨基酸掺入抑制作用的最低水杨酸盐浓度如下：分离的大鼠膈肌，0.1毫摩尔；大鼠肝脏线粒体-微粒体体系，0.1毫摩尔；大鼠肝脏微粒体体系，0.3毫摩尔。3. 发现2.5毫摩尔及以上的水杨酸盐浓度在体外抑制肌酸激酶活性。
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