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1
Inhibitory effect of salicylate on the incorporation of L-(U-14C)leucine into the protein of rat tissue preparations in vitro.水杨酸盐对L-（U-14C）亮氨酸在体外掺入大鼠组织制剂蛋白质中的抑制作用。
Biochem J. 1966 Jun;99(3):703-7. doi: 10.1042/bj0990703.
2
The site of the inhibitory action of salicylate on protein biosynthesis in vitro.水杨酸盐在体外对蛋白质生物合成的抑制作用位点。
J Pharm Pharmacol. 1971 Jul;23(7):519-27. doi: 10.1111/j.2042-7158.1971.tb08701.x.
3
Metabolic effects of hypoglycemic sulfonylureas. I. In vitro effect of sulfonylureas on leucine incorporation and metabolism and on respiration of rat tissues.降血糖磺脲类药物的代谢作用。I. 磺脲类药物对大鼠组织亮氨酸掺入、代谢及呼吸的体外作用。
Biochem Pharmacol. 1967 Dec;16(12):2337-53. doi: 10.1016/0006-2952(67)90220-1.
4
Free amino acid patterns and the distribution of 14C from [U-14C]-L-Leucine, [U-14C]-L-Lysine, and [U-14C]-L-Alanine in the tissues of young adult rats.成年幼鼠组织中游离氨基酸模式以及[U-¹⁴C]-L-亮氨酸、[U-¹⁴C]-L-赖氨酸和[U-¹⁴C]-L-丙氨酸中¹⁴C的分布
J Nutr. 1976 May;106(5):597-605. doi: 10.1093/jn/106.5.597.
5
A comparative study in vivo and in vitro of the ability of ribosomes from Xenopus liver and ovary to incorporate L-[U-14C]leucine.非洲爪蟾肝脏和卵巢核糖体掺入L-[U-¹⁴C]亮氨酸能力的体内和体外比较研究。
Biochem J. 1966 Nov;101(2):369-78. doi: 10.1042/bj1010369.
6
Protein synthesis in liver, muscle, and brain of rats fed a high tyrosine-low protein diet.喂食高酪氨酸-低蛋白饮食的大鼠肝脏、肌肉和大脑中的蛋白质合成。
J Nutr. 1975 Jul;105(7):885-93. doi: 10.1093/jn/105.7.885.
7
Inhibition of protein biosynthesis in mouse liver by salicylate.水杨酸盐对小鼠肝脏蛋白质生物合成的抑制作用。
Biochem Pharmacol. 1971 Jun;20(6):1303-12. doi: 10.1016/0006-2952(71)90362-5.
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Effect of silica on protein biosynthesis by rat liver cell-free systems.二氧化硅对大鼠肝细胞游离体系蛋白质生物合成的影响。
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The biosynthesis of intestinal mucins. The effect of salicylate on glycoprotein biosynthesis by sheep colonic and human gastric mucosal tissues in vitro.肠道黏蛋白的生物合成。水杨酸盐对绵羊结肠和人胃黏膜组织体外糖蛋白生物合成的影响。
Biochem J. 1968 Feb;106(3):645-58. doi: 10.1042/bj1060645.
10
Inhibitory effect of salicylates and cinchophen derivatives on amino-acid incorporation.水杨酸盐和辛可芬衍生物对氨基酸掺入的抑制作用。
Nature. 1967 Mar 4;213(5079):918-9. doi: 10.1038/213918a0.

引用本文的文献

1
Inhibition of protein biosynthesis by salicylate in gastric-mucosal scrapings of pig and man in vitro.水杨酸盐对猪和人胃黏膜刮片蛋白质生物合成的体外抑制作用。
Biochem J. 1969 Mar;111(5):37P. doi: 10.1042/bj1110037pa.
2
The effect of salicylate on the metabolism of normal and stimulated human lymphocytes in vitro.水杨酸盐对体外培养的正常及受刺激的人淋巴细胞代谢的影响。
J Clin Invest. 1971 Jan;50(1):226-30. doi: 10.1172/JCI106478.
3
Impairment of protein synthesis in the rat uterus following intrauterine delivery of indomethacin.吲哚美辛宫内给药后大鼠子宫蛋白质合成的损伤
Br J Pharmacol. 1986 Sep;89(1):199-205. doi: 10.1111/j.1476-5381.1986.tb11136.x.
4
Effect of salicylates on histamine and L-histidine metabolism. Inhibition of imidazoleacetate phosphoribosyl transferase.水杨酸盐对组胺和L-组氨酸代谢的影响。咪唑乙酸磷酸核糖基转移酶的抑制作用。
J Clin Invest. 1976 Jul;58(1):137-41. doi: 10.1172/JCI108442.

本文引用的文献

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The estimation of creatine and of diacetyl.肌酸和双乙酰的测定
Biochem J. 1943;37(5):526-9. doi: 10.1042/bj0370526.
2
Carbohydrate metabolism in experimental salicylism.实验性水杨酸中毒中的碳水化合物代谢
Proc Soc Exp Biol Med. 1955 Mar;88(3):409-11. doi: 10.3181/00379727-88-21602.
3
IN VITRO EFFECT OF SALICYLATE ON AMINO ACID ACCUMULATION BY KIDNEY CORTEX SLICES.水杨酸盐对肾皮质切片氨基酸积累的体外效应
Nature. 1963 Oct 12;200:139-41. doi: 10.1038/200139a0.
4
Effects of salicylate on amino acid incorporation into protein.水杨酸盐对氨基酸掺入蛋白质的影响。
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The action of thyroid hormones at the cell level.甲状腺激素在细胞水平的作用。
Biochem J. 1963 Mar;86(3):408-28. doi: 10.1042/bj0860408.
6
Serum amino acid nitrogen in infancy and childhood.婴幼儿及儿童期的血清氨基酸氮
J Pediatr. 1962 Feb;60:201-5. doi: 10.1016/s0022-3476(62)80037-7.
7
Some effects of sodium salicylate on muscle metabolism.水杨酸钠对肌肉代谢的某些影响。
Br Med J. 1958 May 3;1(5078):1028-30. doi: 10.1136/bmj.1.5078.1028.
8
Action of sodium salicylate and related compounds on tissue metabolism in vitro.水杨酸钠及相关化合物对体外组织代谢的作用。
J Pharmacol Exp Ther. 1956 May;117(1):39-51.

水杨酸盐对L-（U-14C）亮氨酸在体外掺入大鼠组织制剂蛋白质中的抑制作用。

Inhibitory effect of salicylate on the incorporation of L-(U-14C)leucine into the protein of rat tissue preparations in vitro.

作者信息

Dawkins P D, Gould B J, Smith M J

出版信息

Biochem J. 1966 Jun;99(3):703-7. doi: 10.1042/bj0990703.

DOI:10.1042/bj0990703
PMID:5964967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1265061/
Abstract
  1. The inhibitory effect of salicylate, in concentrations ranging from 0.1 to 20mm, on the incorporation of radioactivity from l-[U-(14)C]leucine into the protein of isolated rat diaphragm muscle and of cell-free systems from rat liver was studied. 2. The lowest salicylate concentrations producing significant inhibitions of amino acid incorporation were as follows: isolated rat diaphragm, 0.1mm; rat-liver mitochondrial-microsomal system, 0.1mm; rat-liver microsomal system, 0.3mm. 3. Salicylate concentrations of 2.5mm and above were found to inhibit creatine-kinase activity in vitro.
摘要
  1. 研究了浓度范围为0.1至20毫摩尔的水杨酸盐对L-[U-(14)C]亮氨酸的放射性掺入分离的大鼠膈肌肌肉蛋白以及大鼠肝脏无细胞体系的抑制作用。2. 产生显著氨基酸掺入抑制作用的最低水杨酸盐浓度如下：分离的大鼠膈肌，0.1毫摩尔；大鼠肝脏线粒体-微粒体体系，0.1毫摩尔；大鼠肝脏微粒体体系，0.3毫摩尔。3. 发现2.5毫摩尔及以上的水杨酸盐浓度在体外抑制肌酸激酶活性。