Osieka R, Bruntsch U, Gallmeier W M, Seeber S, Schmidt C G
Dtsch Med Wochenschr. 1976 Aug 6;101(32):1177-82. doi: 10.1055/s-0028-1104236.
In 18 patients with advanced Hodgkin's disease, refractory to previous 'C-MOPP' treatment, a new therapeutic protocol of adriamycin, DTIC, CCNU and bleomycin was introduced. Three patients who had previously failed to respond to any other chemotherapy failed also to respond to the new one. But two complete and 11 partial remissions were obtained in the other 15 patients who had previously responded to C-MOPP before becoming refractory to it. Two patients had further progression of the disease during the new treatment.
在18例晚期霍奇金病患者中,这些患者对先前的“C-MOPP”治疗无效,于是引入了一种由阿霉素、达卡巴嗪、洛莫司汀和博来霉素组成的新治疗方案。之前对任何其他化疗均无反应的3例患者对新方案也无反应。但在之前对C-MOPP有反应但后来变得难治的其他15例患者中,有2例完全缓解,11例部分缓解。2例患者在新治疗期间疾病进一步进展。