Gassmann W, Perenyi L, Pralle H, Graubner M, Schmitz N, Löffler H
Klin Wochenschr. 1981 Mar 16;59(6):267-73. doi: 10.1007/BF01478205.
22 Patients were treated with ABVD, 19 (18 stage IV B 1 stage III B) could be evaluated. No patient with impaired but 7 of 13 patients with intact bone-marrow function achieved a complete remission. A complete remission was also achieved by all 4 patients with a treatment- and disease-free interval but only by 3 of 15 without a free interval. Pretreatment, histology, duration of disease, and age showed no clear prognostic significance with respect to induction of remission. Toxicity was severe especially in patients over 50 years of age. 2 patients discontinued therapy because of gastro-intestinal toxicity. 2 of 8 died of treatment-related causes (1 leukemia, 1 sudden cardiac death). In 3 patients with high-dose mediastinal irradiation a pneumonitis secondary to bleomycin contributed significantly to death. Our results suggest that ABVD is an effective salvage-regimen for some subgroups of MOPP-failures.
22例患者接受了ABVD方案治疗，其中19例（18例IV B期，1例III B期）可进行评估。骨髓功能未受损的患者中无1例达到完全缓解，而骨髓功能正常的13例患者中有7例达到完全缓解。4例处于治疗和疾病无进展间期的患者均达到完全缓解，而15例无疾病无进展间期的患者中只有3例达到完全缓解。预处理、组织学、疾病持续时间和年龄在诱导缓解方面均未显示出明确的预后意义。毒性反应严重，尤其是50岁以上的患者。2例患者因胃肠道毒性而停止治疗。8例中有2例死于与治疗相关的原因（1例白血病，1例心源性猝死）。在3例接受高剂量纵隔照射的患者中，博来霉素继发的肺炎是导致死亡的重要原因。我们的结果表明，ABVD方案对某些MOPP方案治疗失败的亚组患者是一种有效的挽救方案。
