Lawson W, Som H L, Biller H F
Ann Otol Rhinol Laryngol. 1977 Nov-Dec;86(6 Pt 1):751-5. doi: 10.1177/000348947708600606.
The clinical course of papillary adenocarcinoma of the thyroid is delayed but aggressive and lethal in an estimated 11-16% of the patients. Death results in the majority of patients from respiratory obstruction produced by a collar of tumor that has proliferated from residual or multicentric thyroid disease. Review of a large series of cases reveals an incidence of invasion of the aerodigestive tract of 1-6.5%. Six such cases are presented in which resection of the larynx, trachea and pharynx were performed along with total thyroidectomy with local control of the disease and prolonged survival. In five cases conservation surgery was done. Three patients had prior thyroid lobectomy with recurrence and invasion of the air passages 2-5 years later. Intraluminal thyroid carcinoma may be confused with a primary lesion of the larynx, trachea or hypopharynx.
甲状腺乳头状腺癌的临床病程进展缓慢，但具有侵袭性，约11% - 16%的患者会因此死亡。大多数患者的死亡是由于肿瘤环导致的呼吸道梗阻，肿瘤环由残留或多中心甲状腺疾病增殖而来。对大量病例的回顾显示，侵犯气道消化道的发生率为1% - 6.5%。本文介绍了6例此类病例，这些病例均进行了喉、气管和咽部切除以及全甲状腺切除术，实现了疾病的局部控制并延长了生存期。其中5例进行了保留手术。3例患者先前接受过甲状腺叶切除术，2 - 5年后复发并侵犯气道。腔内甲状腺癌可能会与喉、气管或下咽的原发性病变相混淆。
