Comparison of the immune response in serum and bucco-pharyngeal secretions following immunization by different routes with a live hog cholera virus vaccine (Thiverval strain).

The influence of vaccination route on local and systemic immune response was studied with hog cholera virus vaccine. Kinetics of antibody synthesis in serum and bucco-pharyngeal secretion was observed. Results show that, whatever the vaccination route (intranasal or intramuscular) a good systemic and local immune response were induced and pigs resisted to a virulent challenge. However the highest local immune response was obtained by intranasal vaccination with large vaccine dosage (10(7) P.F.U./pig). After a virulent challenge performed by intranasal route, no clear anamnestic immune response was detected in bucco-pharyngeal secretions.