Zak A F, Batuashvili T A
Antibiotiki. 1977 Nov;22(11):970-4.
Chromatographic purity of erythromycin base preparations manufactured in the USSR with various technological procedures and those of 4 foreign firms was studied. All the preparations studied in addition to the main component of erythromycin A contained 5 to 7 per cent of erythromycin C and about 1.5 to 3.5 per cent of a non-identified component possessing a somewhat lower chromatographic mobility than erythromycin C. The admixture of 0.5--1 per cent of anhydroerythmycin was found in many erythromycin preparations. The preparations of some foreign firms contained also a number of additional substances. It was shown that the antimicrobial activity of anhydroerythromycin was 50-60 times lower than that of erythromycin. Direct correla;ion between the level of the antimicrobial activity of the market prepaetions of erythromycin and the level of its chemical purity was noted.
对苏联采用各种工艺生产的红霉素碱制剂以及4家外国公司生产的制剂的色谱纯度进行了研究。除了红霉素A的主要成分外，所有研究的制剂都含有5%至7%的红霉素C和约1.5%至3.5%的一种未鉴定成分，其色谱迁移率略低于红霉素C。在许多红霉素制剂中发现含有0.5% - 1%的脱水红霉素。一些外国公司的制剂还含有一些其他物质。结果表明，脱水红霉素的抗菌活性比红霉素低50 - 60倍。注意到市场上红霉素制剂的抗菌活性水平与其化学纯度水平之间存在直接相关性。
