Ullman S, Dahl M V
Arch Dermatol. 1977 Dec;113(12):1671-3.
Biopsy specimens from 12 patients with necrobiosis lipoidica (diabeticorum) were studied by direct immunofluorescent microscopy. The immunoglobulin IgM was present in blood vessel walls of involved skin from six patients, and the third component of complement (C3) was present in the blood vessel walls of involved skin from seven patients. The immunoglobulin IgA was similarly observed in two patients. In addition, IgM, C3, or fibrinogen were observed at the dermal-epidermal junction of involved skin from seven patients. Necrobiotic areas invariably contained fibrinogen. These findings suggest that an immunecomplex vasculitis may be involved in the pathogenesis of necrobiosis lipoidica.
对12例类脂质渐进性坏死（糖尿病性）患者的活检标本进行了直接免疫荧光显微镜检查。6例患者受累皮肤的血管壁中存在免疫球蛋白IgM，7例患者受累皮肤的血管壁中存在补体第三成分（C3）。在2例患者中同样观察到免疫球蛋白IgA。此外，在7例患者受累皮肤的真皮-表皮交界处观察到IgM、C3或纤维蛋白原。渐进性坏死区域始终含有纤维蛋白原。这些发现提示免疫复合物性血管炎可能参与了类脂质渐进性坏死的发病机制。
