Soler N G, McConnachie P R
Postgrad Med J. 1983 Dec;59(698):759-62. doi: 10.1136/pgmj.59.698.759.
To investigate whether HLA-A, -B, -C, and -DR alloantigen frequencies are different in diabetic patients with and without necrobiosis lipoidica diabeticorum we studied 37 insulin-dependent (Type I) diabetics, 15 with and 22 without necrobiosis, and 96 normal control subjects. Compared to controls Type I diabetics had increased frequencies of B8, CW3, and DR4 and decreased frequencies of DR5 and DR7. Diabetics with necrobiosis differed from diabetics without necrobiosis only in that HLA-A2 was significantly less frequent in patients with necrobiosis. It is suggested that the lack of major differences between patients with and without necrobiosis argues in favour of the role of metabolic and/or vascular rather than genetic factors in the aetiology of necrobiosis.
为了研究伴有和不伴有糖尿病性类脂质渐进性坏死的糖尿病患者中HLA - A、 - B、 - C和 - DR同种异体抗原频率是否存在差异，我们研究了37例胰岛素依赖型（I型）糖尿病患者，其中15例伴有糖尿病性类脂质渐进性坏死，22例不伴有，以及96名正常对照者。与对照组相比，I型糖尿病患者B8、CW3和DR4的频率增加，而DR5和DR7的频率降低。伴有糖尿病性类脂质渐进性坏死的糖尿病患者与不伴有该病症的糖尿病患者的不同之处仅在于，伴有糖尿病性类脂质渐进性坏死的患者中HLA - A2的频率显著较低。有人提出，伴有和不伴有糖尿病性类脂质渐进性坏死的患者之间缺乏主要差异，这支持了代谢和/或血管因素而非遗传因素在糖尿病性类脂质渐进性坏死病因学中的作用。
