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1
Fermentation studies with Streptomyces griseus. II. Synthetic media for the production of streptomycin.灰色链霉菌的发酵研究。II. 用于生产链霉素的合成培养基。
Appl Microbiol. 1966 Sep;14(5):706-10. doi: 10.1128/am.14.5.706-710.1966.
2
Fermentation studies with Streptomyces griseus. I. Carbohydrate sources for the production of protease and streptomycin.灰色链霉菌的发酵研究。I. 用于蛋白酶和链霉素生产的碳水化合物来源。
Appl Microbiol. 1965 Sep;13(5):669-72. doi: 10.1128/am.13.5.669-672.1965.
3
EFFECTS OF MINERALS ON NEOMYCIN PRODUCTION BY STREPTOMYCES FRADIAE.矿物质对弗氏链霉菌产生新霉素的影响。
Appl Microbiol. 1965 Mar;13(2):190-3. doi: 10.1128/am.13.2.190-193.1965.
4
Antibiotic production of hyphal fractions of Streptomyces griseus. II. Streptomycin production of different fractions obtained by density gradient centrifugation.灰色链霉菌菌丝部分的抗生素产生。II. 通过密度梯度离心获得的不同部分的链霉素产生。
Appl Microbiol. 1967 Sep;15(5):1010-3.
5
[Influence of perfluorodecalin on growth of actinomycetes and intensification of Streptomycin and daunorubicin production by the genus Streptomyces kind bacteria in submerged culture].[全氟萘烷对放线菌生长及链霉菌属细菌在深层培养中生产链霉素和柔红霉素的强化作用]
Antibiot Khimioter. 2014;59(7-8):3-7.
6
[Study of foam formation during streptomycin biosynthesis of different culture media].
Antibiotiki. 1968 Feb;13(2):120-6.
7
[Protoplasts of Streptomyces griseus and its auxotrophic derivatives].
Mikrobiol Zh (1978). 1984 Sep-Oct;46(5):3-8.
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Biosynthesis of streptomycin. Purification and properties of a dTDP-L-dihydrostreptose: streptidine-6-phosphate dihydrostreptosyltransferase from Streptomyces griseus.链霉素的生物合成。来自灰色链霉菌的dTDP-L-二氢链霉糖：链霉胍-6-磷酸二氢链霉糖基转移酶的纯化及性质
Eur J Biochem. 1980 Mar;105(1):139-44. doi: 10.1111/j.1432-1033.1980.tb04483.x.
9
Selective strategies for antibiotic fermentation, Part II: Effect of aeration on streptomycin production by Streptomyces griseus JB-19.抗生素发酵的选择性策略，第二部分：通气对灰色链霉菌JB - 19产生链霉素的影响
Hindustan Antibiot Bull. 1991 Feb-Nov;33(1-4):14-8.
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[Study of the effect of aeration and agitation conditions on the cultivation of a streptomycin-producing microorganism].通气与搅拌条件对链霉素产生菌培养影响的研究
Antibiotiki. 1971 Jul;16(7):613-5.

引用本文的文献

1
Development of a defined medium fermentation process for physostigmine production by Streptomyces griseofuscus.灰色链霉菌生产毒扁豆碱的特定培养基发酵工艺的开发。
Appl Microbiol Biotechnol. 1996 Jan;44(5):568-75. doi: 10.1007/BF00172487.
2
Biochemistry and regulation of streptomycin and mannosidostreptomycinase (alpha-D-mannosidase) formation.链霉素和甘露糖苷链霉蛋白酶（α-D-甘露糖苷酶）形成的生物化学及调控
Bacteriol Rev. 1970 Mar;34(1):1-19. doi: 10.1128/br.34.1.1-19.1970.

本文引用的文献

1
Observations on Streptomyces griseus: II. Nitrogen Sources for Growth and Streptomycin Production.灰色链霉菌的观察：II. 生长及链霉素产生的氮源
J Bacteriol. 1948 Sep;56(3):305-13.
2
Studies on the Nutritional Requirements of Streptomyces griseus for the Formation of Streptomycin.灰色链霉菌产生链霉素的营养需求研究
J Bacteriol. 1946 Aug;52(2):223-6.
3
Metabolism and the Chemical Nature of Streptomyces griseus.灰色链霉菌的代谢与化学性质
J Bacteriol. 1946 Jun;51(6):753-9. doi: 10.1128/jb.51.6.753-759.1946.
4
Fermentation studies with Streptomyces griseus. I. Carbohydrate sources for the production of protease and streptomycin.灰色链霉菌的发酵研究。I. 用于蛋白酶和链霉素生产的碳水化合物来源。
Appl Microbiol. 1965 Sep;13(5):669-72. doi: 10.1128/am.13.5.669-672.1965.

灰色链霉菌的发酵研究。II. 用于生产链霉素的合成培养基。

Fermentation studies with Streptomyces griseus. II. Synthetic media for the production of streptomycin.

作者信息

Shirato S, Motoyama H

出版信息

Appl Microbiol. 1966 Sep;14(5):706-10. doi: 10.1128/am.14.5.706-710.1966.

DOI:10.1128/am.14.5.706-710.1966
PMID:5970459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1058400/
Abstract

Synthetic media for streptomycin fermentation were studied to determine which media gave highest yields of streptomycin. The effect of salts on streptomycin production by Streptomyces griseus was examined, and a suitable combination of salts was established in a glucose-casein medium. This medium yielded 3,000 mug/ml of the antibiotic with an inoculum of 1.6%. Substitution of amino acids for casein was examined. Of 17 amino acids tested, best results were obtaind with sodium aspartate. Substitution of ammonium salts was tried, and an excellent streptomycin yield was obtained with a medium containing ammonium citrate.

摘要

对链霉素发酵的合成培养基进行了研究，以确定哪种培养基能产生最高产量的链霉素。研究了盐类对灰色链霉菌产生链霉素的影响，并在葡萄糖 - 酪蛋白培养基中确定了合适的盐类组合。这种培养基在接种量为1.6%时可产生3000微克/毫升的抗生素。研究了用氨基酸替代酪蛋白的情况。在所测试的17种氨基酸中，天冬氨酸钠取得了最佳结果。尝试了替代铵盐的情况，在含有柠檬酸铵的培养基中获得了优异的链霉素产量。