[全氟萘烷对放线菌生长及链霉菌属细菌在深层培养中生产链霉素和柔红霉素的强化作用]
[Influence of perfluorodecalin on growth of actinomycetes and intensification of Streptomycin and daunorubicin production by the genus Streptomyces kind bacteria in submerged culture].
作者信息
Bakulin V M, Tumanov A S, Martinson E A, Litvinec S G, Bakulin M K, Kalininski V B
出版信息
Antibiot Khimioter. 2014;59(7-8):3-7.
Addition of perfluorodecalin with gas-transporting function to the liquid medium during submerged cultivation of actinomycetes of the genus Streptomyces resulted in higher intensity and level of the biomass synthesis and increased production of streptomycin and daunorubicin. Addition of perfluorodecalin to the medium provided a 2.0-2.3-fold surpass of the maximum antibiotic production (achieved by the 120th-144th hours of the culture growth) vs. the antibiotic accumulation peaks in the control.
在链霉菌属放线菌的深层培养过程中，向液体培养基中添加具有气体传输功能的全氟萘烷，可提高生物量合成的强度和水平，并增加链霉素和柔红霉素的产量。向培养基中添加全氟萘烷后，抗生素的最大产量（在培养生长的第120至144小时达到）比对照中的抗生素积累峰值高出2.0至2.3倍。
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