雌激素对未成熟雏鸡核黄素结合蛋白的诱导作用。
Oestrogen induction of riboflavin-binding protein in immature chicks.
作者信息
Murthy U S, Adiga P R
出版信息
Biochem J. 1977 Sep 15;166(3):647-50. doi: 10.1042/bj1660647.
Abstract
In hyperthyroid chicks, oestrogen-induced plasma accumulation of riboflavin-binding protein was diminished, whereas the reverse situation prevailed in hypothyroid birds. Under hyperthyroid conditions, higher concentrations of oestrogen were required to elicit a response comparable with that obtained in normal birds treated with lower concentrations of the hormone. Elevated hepatic cytochrome P-450 concentrations and decreased half-life of the induced protein in hyperthyroid animals suggest that higher catabolic rates of the inducer and induced protein are contributory factors to the diminished response.
摘要
在甲状腺功能亢进的雏鸡中，雌激素诱导的核黄素结合蛋白血浆蓄积减少，而在甲状腺功能减退的鸟类中则出现相反的情况。在甲状腺功能亢进的条件下，需要更高浓度的雌激素才能引发与用较低浓度该激素处理的正常鸟类所获得的反应相当的反应。甲状腺功能亢进动物肝脏细胞色素P - 450浓度升高以及诱导蛋白半衰期缩短表明，诱导剂和诱导蛋白的较高分解代谢率是导致反应减弱的因素。
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