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Energy-dependent uptake of arsenite by rat liver mitochondria.大鼠肝脏线粒体对亚砷酸盐的能量依赖性摄取。
Biochem J. 1977 Oct 15;168(1):129-32. doi: 10.1042/bj1680129.
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Phosphate carrier of liver mitochondria: the reaction of its SH groups with mersalyl, 5,5'-dithio-bis-nitrobenzoate, and N-ethylmaleimide and the modulation of reactivity by the energy state of the mitochondria.肝线粒体的磷酸盐载体：其巯基与汞撒利、5,5'-二硫代双硝基苯甲酸和N-乙基马来酰亚胺的反应以及线粒体能量状态对反应性的调节
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Phosphate transport and proteins with SH groups in rat liver mitochondria.大鼠肝线粒体中的磷酸盐转运及含巯基的蛋白质
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Mersalyl prevents the Tl-induced permeability transition pore opening in the inner membrane of Ca-loaded rat liver mitochondria.汞撒利可防止铊诱导的钙负载大鼠肝线粒体内膜通透性转换孔开放。
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Mitochondrial diaphorases as NAD⁺ donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition.线粒体黄递酶作为 NAD⁺ 的供体，为柠檬酸循环的片段提供支持，在呼吸抑制期间通过底物水平磷酸化生成 ATP。
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2
Ion permeability induction by the SH cross-linking reagents in rat liver mitochondria is inhibited by the free radical scavenger, butylhydroxytoluene.大鼠肝线粒体中SH交联试剂诱导的离子通透性受到自由基清除剂丁基羟基甲苯的抑制。
J Bioenerg Biomembr. 1987 Jun;19(3):191-202. doi: 10.1007/BF00762412.

本文引用的文献

1
On the mechanism of oxidative phosphorylation. IV. Mitochondrial swelling caused by arsenite in combination with 2,3-dimercaptopropanol and by cadmium ion.论氧化磷酸化的机制。IV. 亚砷酸盐与2,3-二巯基丙醇结合以及镉离子所引起的线粒体肿胀
Biochemistry. 1962 Mar;1:276-81. doi: 10.1021/bi00908a014.
2
On the mechanism of oxidative phosphorylation. II. Effects of arsenite alone and in combination with 2,3-dimercaptopropanol.论氧化磷酸化的机制。II. 亚砷酸盐单独及与2,3-二巯基丙醇联合使用的效果。
J Biol Chem. 1961 Oct;236:2772-8.
3
The effect of arsenite on rat-liver mitochondria.亚砷酸盐对大鼠肝脏线粒体的影响。
FEBS Lett. 1971 Oct 1;17(2):342-344. doi: 10.1016/0014-5793(71)80183-7.
4
Inhibition of respiration under the control of azide uptake by mitochondria.线粒体对叠氮化物摄取的控制下呼吸的抑制作用。
Eur J Biochem. 1967 Jun;1(4):439-46. doi: 10.1007/978-3-662-25813-2_60.
5
Intramitochondrial substrate concentration as a factor controlling metabolism. The role of interanion competition.线粒体内底物浓度作为控制新陈代谢的一个因素。阴离子间竞争的作用。
Biochem J. 1968 Sep;109(2):239-46. doi: 10.1042/bj1090239.
6
The effects of colloids on the appearance and substrate permeability of rat liver mitochondria.胶体对大鼠肝脏线粒体外观及底物通透性的影响。
J Bioenerg. 1971 Aug;2(3):221-32. doi: 10.1007/BF01648917.
7
The dependence on energy and K+ ions of the accumulation of glutamate by rat liver mitochondria.大鼠肝线粒体对谷氨酸积累的能量和钾离子依赖性。
Arch Biochem Biophys. 1973 Sep;158(1):236-41. doi: 10.1016/0003-9861(73)90617-6.
8
Comparison of the effects of disulfiram and dimercaptopropanol arsenite on mitochondrial structure and function.双硫仑和二巯丙醇亚砷酸盐对线粒体结构和功能影响的比较。
Biochem Pharmacol. 1967 Nov;16(11):2155-61. doi: 10.1016/0006-2952(67)90014-7.

大鼠肝脏线粒体对亚砷酸盐的能量依赖性摄取。

Energy-dependent uptake of arsenite by rat liver mitochondria.

作者信息

Harris E J, Achenjang F M

出版信息

Biochem J. 1977 Oct 15;168(1):129-32. doi: 10.1042/bj1680129.

DOI:10.1042/bj1680129
PMID:597259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1184124/
Abstract

Uptake of arsenite by rat liver mitochondria is energy-dependent, as shown by comparing values without and with either uncoupling agent or respiratory inhibitor present. The uptake is inhibited by mersalyl and N-ethylmaleimide, which can be used as 'stopping' agents to obtain uptake kinetics. At 20 degrees C the process is nearly complete in 1 min. The relation between the quantity in the energized mitochondria and the applied concentration corresponds to at least two different modes of binding of the arsenite. Competition occurs between arsenite and other anions (for example, phosphate) for intramitochondrial accumulation.

摘要

大鼠肝线粒体对亚砷酸盐的摄取是能量依赖性的，这一点可通过比较有无解偶联剂或呼吸抑制剂存在时的摄取值来证明。摄取受到汞撒利和N - 乙基马来酰胺的抑制，它们可用作“终止”剂以获得摄取动力学。在20摄氏度时，该过程在1分钟内几乎完成。线粒体中活化状态下的量与施加浓度之间的关系至少对应于亚砷酸盐的两种不同结合模式。亚砷酸盐与其他阴离子（例如磷酸盐）之间存在线粒体内部积累的竞争。