对C3H/HeJ小鼠重复给予红细胞包封蛋白的免疫学评估。
Immunological evaluation of repeated administration of erythrocyte-entrapped protein to C3H/HeJ mice.
作者信息
Fiddler M B, Hudson L D, Desnick R J
出版信息
Biochem J. 1977 Nov 15;168(2):141-5. doi: 10.1042/bj1680141.
Abstract
The immunogenicity of heterologous protein entrapped in autologous erythrocytes was evaluated in a mouse system. Multiple intravenous administrations of an erythrocyte-entrapped bovine beta-glucuronidase preparation resulted in little, if any, immunological response to the entrapped protein or erythrocyte carrier. Erythrocyte entrapment also protected protein from circulating antibody elicited by prior subcutaneous sensitization with unentrapped enzyme in adjuvant. Thus erythrocyte entrapment may protect potentially immunogenic agents from immunological surveillance.
摘要
在小鼠系统中评估了包裹于自体红细胞中的异源蛋白质的免疫原性。多次静脉注射包裹有牛β-葡萄糖醛酸酶的红细胞制剂，对包裹的蛋白质或红细胞载体几乎没有产生免疫反应（即便有，也非常少）。红细胞包裹还能保护蛋白质免受先前皮下注射未包裹的佐剂酶引发的循环抗体的影响。因此，红细胞包裹可能会保护潜在的免疫原性物质免受免疫监视。
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