• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

The metabolism of imipramine and its metabolites by rat liver microsomes.

作者信息

Bickel M H, Baggiolini M

出版信息

Biochem Pharmacol. 1966 Aug;15(8):1155-69. doi: 10.1016/0006-2952(66)90281-4.

DOI:10.1016/0006-2952(66)90281-4
PMID:5973159
Abstract
摘要

相似文献

1
The metabolism of imipramine and its metabolites by rat liver microsomes.大鼠肝微粒体对丙咪嗪及其代谢产物的代谢作用。
Biochem Pharmacol. 1966 Aug;15(8):1155-69. doi: 10.1016/0006-2952(66)90281-4.
2
High-performance liquid chromatographic method for the analysis of imipramine metabolism in vitro by liver and brain microsomes.用高效液相色谱法分析肝脏和脑微粒体体外对丙咪嗪的代谢。
J Chromatogr B Biomed Appl. 1995 Nov 17;673(2):251-8. doi: 10.1016/0378-4347(95)00274-x.
3
Metabolic interconversions and binding of imipramine, imipramine-N-oxide, and desmethylimipramine in rat liver slices.
Xenobiotica. 1971 Nov;1(6):631-41. doi: 10.3109/00498257109112273.
4
Effect of pregnenolone-16 alpha-carbonitrile on the biliary and urinary excretion of imipramine and some of its metabolites in rats.孕烯醇酮-16α-腈对大鼠体内丙咪嗪及其某些代谢产物胆汁和尿液排泄的影响。
Arzneimittelforschung. 1982;32(10):1298-301.
5
Kinetic properties of the metabolism of imipramine and desipramine in isolated rat hepatocytes.丙咪嗪和地昔帕明在离体大鼠肝细胞中代谢的动力学特性。
Biochem Pharmacol. 1990 Jan 15;39(2):367-72. doi: 10.1016/0006-2952(90)90036-k.
6
Metabolism of amitriptyline, nortriptyline, imipramine and desipramine to yield hydroxylamines.
J Pharm Pharmacol. 1973 Apr;25(4):335-6. doi: 10.1111/j.2042-7158.1973.tb10018.x.
7
N-oxidation of imipramine by isolated perfused rat and rabbit lung.丙咪嗪在离体灌注大鼠和兔肺中的N-氧化作用。
Life Sci. 1980 Apr 28;26(17):1411-21. doi: 10.1016/0024-3205(80)90044-2.
8
Sex differences in the uptake and retention of imipramine and desmethylimipramine in the rat lung.
Life Sci. 1982 Mar 1;30(9):757-60. doi: 10.1016/0024-3205(82)90610-5.
9
[On the absorption and metabolism of imipramine by the rat brain after single and repeated doses].[单次及重复给药后大鼠脑对丙咪嗪的吸收与代谢]
Psychopharmacologia. 1969;14(1):74-82. doi: 10.1007/BF00401536.
10
Studies on the demethylation, hydroxylation and N-oxidation of imipramine in rat liver.
Biochem Pharmacol. 1970 Apr;19(4):1363-9. doi: 10.1016/0006-2952(70)90051-1.

引用本文的文献

1
Discovery of Novel Nonpeptidic PAR2 Ligands.新型非肽类PAR2配体的发现。
ACS Med Chem Lett. 2020 May 22;11(6):1316-1323. doi: 10.1021/acsmedchemlett.0c00154. eCollection 2020 Jun 11.
2
Clinical and biochemical results of a fatal case of desipramine intoxication.一例地昔帕明中毒致死病例的临床及生化检查结果
Psychopharmacologia. 1967;10(5):431-6. doi: 10.1007/BF00403984.
3
Metabolism of 14 C-imipramine. 3. Conversions by rat tissues.14C-丙咪嗪的代谢。3. 大鼠组织的转化
Psychopharmacologia. 1970 Aug 19;18(1):26-37. doi: 10.1007/BF00402381.
4
[On the absorption and metabolism of imipramine by the rat brain after single and repeated doses].[单次及重复给药后大鼠脑对丙咪嗪的吸收与代谢]
Psychopharmacologia. 1969;14(1):74-82. doi: 10.1007/BF00401536.
5
Metabolism of 14C-imipramine. II. Urinary metabolites in man.14C-丙咪嗪的代谢。II. 人体尿液中的代谢产物
Psychopharmacologia. 1969;15(3):207-25. doi: 10.1007/BF00411170.
6
Uptake, subcellular distribution, and transfer processes of imipramine and its metabolites formed in rat liver perfusion systems.丙咪嗪及其在大鼠肝脏灌注系统中形成的代谢产物的摄取、亚细胞分布和转运过程。
Naunyn Schmiedebergs Arch Pharmacol. 1974;284(4):339-52. doi: 10.1007/BF00504703.
7
Hepatic and extrahepatic metabolism of the psychotropic drugs, chlorpromazine, imipramine, and imipramine-N-oxide.精神药物氯丙嗪、丙咪嗪和丙咪嗪 -N-氧化物的肝脏和肝外代谢。
Naunyn Schmiedebergs Arch Pharmakol. 1971;268(3):334-47. doi: 10.1007/BF00997266.
8
Metabolic interaction between imipramine and carbamazepine in vivo and in vitro in rats.
Naunyn Schmiedebergs Arch Pharmacol. 1988 Jan;337(1):105-10. doi: 10.1007/BF00169485.
9
Comparison of the metabolism of the three antidepressants amitriptyline, imipramine, and chlorimipramine in vitro in rat liver microsomes.
Psychopharmacology (Berl). 1986;88(4):505-13. doi: 10.1007/BF00178516.
10
Alteration of cytochrome P-450 by prolonged administration of imipramine and/or lithium to rats.长期给大鼠服用丙咪嗪和/或锂对细胞色素P-450的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1990 Aug;342(2):234-40. doi: 10.1007/BF00166970.