苯丙胺、芬氟拉明及相关化合物在大鼠味觉厌恶实验中的相对效价。
Comparative potencies of amphetamine, fenfluramine and related compounds in taste aversion experiments in rats.
作者信息
Booth D A, Pilcher C W, D'Mello G D, Stolerman I P
出版信息
Br J Pharmacol. 1977 Dec;61(4):669-77. doi: 10.1111/j.1476-5381.1977.tb07560.x.
Abstract
1 Rats failed to drink a flavoured solution when its consumption had been followed by injection of amphetamine (conditioned taste aversion).2 There was very little difference between the potencies of (+)- and (-)-amphetamine.3p-Chloromethamphetamine was a more potent aversive agent than methamphetamine.4 Strong taste aversions were also conditioned with other congeners of amphetamine. The rank order of potency was: fenfluramine > chlorphentermine >p-hydroxyamphetamine.5 Cocaine induced only moderate taste aversions, even at high doses.6 Aversive potency did not appear to be correlated with known neurochemical actions of the drugs or with behavioural stimulation, but appeared to be a central action which may have been linked to anorexigenic potency or time course of action.
摘要
- 当大鼠饮用一种调味溶液后被注射苯丙胺时，它们就不再饮用该溶液（条件性味觉厌恶）。2. （+）-苯丙胺和（-）-苯丙胺的效力几乎没有差异。3. 对氯苯丙胺是比甲基苯丙胺更强效的厌恶剂。4. 强烈的味觉厌恶也可由苯丙胺的其他同系物诱发。效力的排序为：芬氟拉明＞氯苯丁胺＞对羟基苯丙胺。5. 即使大剂量使用，可卡因也仅诱发中度的味觉厌恶。6. 厌恶效力似乎与药物已知的神经化学作用或行为兴奋无关，而似乎是一种中枢作用，可能与厌食效力或作用时程有关。
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