尼古丁诱导大鼠产生的条件性味觉厌恶的特征
Characteristics of conditioned taste aversion produced by nicotine in rats.
作者信息
Kumar R, Pratt J A, Stolerman I P
出版信息
Br J Pharmacol. 1983 May;79(1):245-53. doi: 10.1111/j.1476-5381.1983.tb10518.x.
Abstract
1 Nicotine produced conditioned taste aversions in rats which were directly related to the dose of nicotine and to the number of conditioning trials. 2 The tobacco alkaloid (-)-nicotine was four to five times as potent as its stereoisomer, (+)-nicotine. 3 Mecamylamine but not hexamethonium blocked the development of taste aversions produced by nicotine. 4 Mecamylamine did not block the development of taste aversions produced by apomorphine. 5 Prolonged treatment with mecamylamine prior to conditioning did not produce supersensitivity to nicotine.
摘要
- 尼古丁会使大鼠产生条件性味觉厌恶，这与尼古丁的剂量以及条件反射试验的次数直接相关。2. 烟草生物碱（-）-尼古丁的效力是其立体异构体（+）-尼古丁的四到五倍。3. 美加明而非六甲铵能阻断尼古丁引起的味觉厌恶的形成。4. 美加明不能阻断阿扑吗啡引起的味觉厌恶的形成。5. 在条件反射前用美加明进行长期治疗不会产生对尼古丁的超敏反应。
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