前列腺素F2α的16-芳氧基类似物对前列腺素内过氧化物反应性制剂的作用
Actions of 16-aryloxy analogues of prostaglandin F2alpha on preparations responsive to prostaglandin endoperoxides.
作者信息
Jones R L, Marr C G
出版信息
Br J Pharmacol. 1977 Dec;61(4):694-6. doi: 10.1111/j.1476-5381.1977.tb07563.x.
Abstract
On four prostaglandin endoperoxide-sensitive preparations, namely human platelets in vitro, rabbit aortic strip, guinea-pig tracheal chain and pig blood pressure, ICI 79939 and its 11-oxo analogue mimicked the actions of 11,9-(epoxymethano) prostaglandin H2, and were considerably more active than either prostaglandin F2alpha or ICI 81008. It is suggested that this activity of ICI 79939 may contribute to its toxicity in experimental animals.
摘要
在四种对前列腺素内过氧化物敏感的制剂上，即体外培养的人血小板、兔主动脉条、豚鼠气管链和猪血压，ICI 79939及其11-氧代类似物模拟了11,9-(环氧甲叉)前列腺素H2的作用，并且比前列腺素F2α或ICI 81008的活性都要强得多。有人认为ICI 79939的这种活性可能是其在实验动物中产生毒性的原因。
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Thromb Res. 1974 Sep;5(3):291-9. doi: 10.1016/0049-3848(74)90168-6.
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