Welburn P J, Jones R L
Prostaglandins. 1978 Feb;15(2):287-96. doi: 10.1016/0090-6980(78)90168-5.
Three 16-aryloxy analogues of PGF2alpha are potent, full agonists on the isolated rabbit jejunum. Their actions are more prolonged than that of PGF2alpha, and radioactive tracer studies with one of the analogues reveal a slower wash-out of the analogue compared to PGF2alpha, under superfusion conditions. During the prolonged contractile response diminished responses to PGF2alpha were obtained: this effect was investigated in terms of receptor desensitization. The actions of these analogues were also investigated on the isolated guinea-pig ileum and the rabbit oviduct in vivo.
前列腺素F2α的三种16 - 芳氧基类似物对离体兔空肠是强效的完全激动剂。它们的作用比前列腺素F2α更持久，并且用其中一种类似物进行的放射性示踪研究表明，在超灌注条件下，与前列腺素F2α相比，该类似物的洗脱速度较慢。在延长的收缩反应期间，对前列腺素F2α的反应减弱：根据受体脱敏对这种效应进行了研究。还在体内对分离的豚鼠回肠和兔输卵管研究了这些类似物的作用。
