Kawanami S, Itoyama Y, Kuroiwa Y
J Neurol. 1976 Jul 15;213(1):33-40. doi: 10.1007/BF00316337.
Cellular hypersensitivity in myasthenia gravis (MG) to the thymus, muscles and peripheral nerves was examined by the method of the leucocyte migration inhibition test. The group of MG patients without thymoma had inhibition of leucocyte migration by thymus antigens. After thymectomy, they had a normal value of leucocyte migration. However, in the group of MG patients with thymoma, the inhibition of leucocyte migration by thymus antigens was observed after thymectomy. No significant inhibition of leucocyte migration was observed using muscle and peripheral nerve antigens. Cellular immunity in myasthenia gravis and the pathogenesis of the disease was discussed.
采用白细胞游走抑制试验方法，检测了重症肌无力（MG）患者对胸腺、肌肉和周围神经的细胞超敏反应。无胸腺瘤的MG患者组对胸腺抗原有白细胞游走抑制现象。胸腺切除术后，他们的白细胞游走值恢复正常。然而，在有胸腺瘤的MG患者组中，胸腺切除术后仍观察到对胸腺抗原有白细胞游走抑制现象。使用肌肉和周围神经抗原未观察到明显的白细胞游走抑制。讨论了重症肌无力的细胞免疫及疾病发病机制。
