Kawanami S, Kanaide A, Itoyama Y, Kuroiwa Y
J Neurol Neurosurg Psychiatry. 1979 Aug;42(8):734-40. doi: 10.1136/jnnp.42.8.734.
Mitogen-induced blastoid transformation of peripheral blood lymphocytes from patients with myasthenia gravis was studied using a microplate culture technique and evaluated with 3H-thymidine incorporation. It was found that both phytohaemagglutinin and pokeweed mitogen responses decreased significantly in patients with myasthenia gravis. In myasthenic crisis, indices of stimulation by phytohaemagglutination became very low. The autologous plasma neither inhibited nor facilitated mitogenic responses of lymphocytes. The decreased mitogen responsiveness of lymphocytes suggests that part of the T lymphocyte function is subnormal in myasthenia.
采用微孔板培养技术研究了重症肌无力患者外周血淋巴细胞的丝裂原诱导的母细胞样转化，并通过³H-胸腺嘧啶核苷掺入法进行评估。结果发现，重症肌无力患者的植物血凝素和商陆丝裂原反应均显著降低。在重症肌无力危象时，植物血凝素刺激指数变得非常低。自体血浆既不抑制也不促进淋巴细胞的丝裂原反应。淋巴细胞丝裂原反应性降低表明重症肌无力患者部分T淋巴细胞功能低于正常水平。
