可乐定对人类睡眠模式的影响。
Effect of clonidine on sleep patterns in man.
作者信息
Autret A, Minz M, Beillevaire T, Cathala H P, Schmitt H
出版信息
Eur J Clin Pharmacol. 1977 Dec 16;12(5):319-22. doi: 10.1007/BF00562444.
PMID:598402
Abstract
Clonidine (300 microgram orally) increased in man the total duration of sleep and strikingly reduced the duration of REM sleep. Yohimbine (10 mg per os) did not alter the sleep patterns in man but antagonized the effects of clonidine. These results provide evidence that an alpha sympathomimetic mechanism could suppress REM sleep and increased the total duration of sleep.
摘要
可乐定（口服300微克）可增加人体的总睡眠时间，并显著缩短快速眼动睡眠的时间。育亨宾（口服10毫克）不会改变人体的睡眠模式，但会拮抗可乐定的作用。这些结果证明，一种α拟交感神经机制可能会抑制快速眼动睡眠并增加总睡眠时间。
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