Sun C N, Hsu D, Pinkerton H
Exp Pathol (Jena). 1977 Jul-Aug;14(1-2):9-15. doi: 10.1016/s0014-4908(77)80086-0.
This study is dealing with the infection patterns of adenovirus type 2 and type 12 on human fibroblast cell lines, KB, WI and MAF. With the exception of Ad -12 leads to WI, many intranuclear viral particles were present. None of these second passages (Ad-2 WI-WI, Ad-12 WI-WI, Ad-2 MAF-MAF, Ad-12 MAF-MAF) was found to have viral production. This indicates that the injections on both WI and MAF cells caused by both Ad-2 and Ad-12 cannot be serially transmitted. However, when these infected cells were used to expose KB cells, significant viral yields were obtained. This shows that the infected cells might still carry the viral specific antigens although no visible virions were observed.
本研究探讨了腺病毒2型和12型在人成纤维细胞系KB、WI和MAF上的感染模式。除了Ad -12感染WI细胞外，细胞核内存在许多病毒颗粒。这些第二代传代培养（Ad-2 WI-WI、Ad-12 WI-WI、Ad-2 MAF-MAF、Ad-12 MAF-MAF）均未发现有病毒产生。这表明Ad-2和Ad-12对WI和MAF细胞的感染均不能连续传播。然而，当用这些感染细胞去感染KB细胞时，获得了大量的病毒产量。这表明，尽管未观察到可见的病毒粒子，但感染细胞可能仍携带病毒特异性抗原。
