Harboe M, Folling I
Lancet. 1976 Aug 7;2(7980):285-9. doi: 10.1016/s0140-6736(76)90734-0.
Intravenous injection of the divalent X-ray contrast medium ioglycamic acid ("Biligram") induced intravascular precipitation and sudden death of a patient owing to reaction with his monoclonal macroglobulin. Mice reacted similarly in passive transfer experiments. The corresponding monovalent compound, acetrizoic acid, was also bound to the IgM but did not induce precipitation and had no apparent ill-effects on mice in passive transfer experiments.
静脉注射二价X射线造影剂碘甘氨酸（“必利格兰姆”），因与患者的单克隆巨球蛋白发生反应，导致血管内沉淀并致使患者猝死。在被动转移实验中，小鼠也有类似反应。相应的单价化合物醋碘苯酸也与IgM结合，但未引起沉淀，且在被动转移实验中对小鼠没有明显不良影响。
