呋喃妥因对雄性小鼠减数分裂的影响。
Effect of nitrofurantoin on meiosis of the male mouse.
作者信息
Fonatsch C
出版信息
Hum Genet. 1977 Dec 23;39(3):345-51. doi: 10.1007/BF00295430.
PMID:598843
Abstract
The effects of nitrofurantoin [N-(5-nitro-2-furfurylidine)-1-amino-hydantoin] on chromosomes of primary and secondary spermatocytes of mice were studied. No mutagenic activity was detectable after application of either 8 mg/kg or 40 mg/kg nitrofurantoin. An increase in the univalent rates and a decrease in the chiasma frequencies was observed in treated animals. The probable origins of these effects are discussed.
摘要
研究了呋喃妥因[N-(5-硝基-2-糠叉基)-1-氨基乙内酰脲]对小鼠初级和次级精母细胞染色体的影响。给予8mg/kg或40mg/kg呋喃妥因后均未检测到诱变活性。在处理过的动物中观察到单价体率增加和交叉频率降低。讨论了这些影响的可能来源。
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