Rollag M D, Morgan R J, Niswender G D
ISA Trans. 1977;16(4):91-6.
Due to the anatomical location of the pineal gland on the dorsal surface of the third ventricle, melatonin may be secreted either into the blood or into the cerebrospinal fluid (CSF). To determine the route of secretion in sheep, simultaneous samples of blood from the jugular vein and of CSF from the cisterna magna were obtained during an endogenous surge of melatonin secretion. Making the assumption that the distribution of melatonin in sheep could be modeled as a time-invariant linear system, two simultaneous equations were developed in which the only two unknowns, the input function into the blood and into the ventricles, were convolved with weighting functions derived from the concentration profiles obtained following the injection of known quantities of melatonin into the jugular vein and into the lateral ventricle. The respective input functions were evaluated following deconvolution in the frequency domain. The quantity of melatonin secreted into the blood was more than 100 times greater than that secreted into the CSF.
由于松果体位于第三脑室背侧的解剖位置，褪黑素可能分泌到血液或脑脊液（CSF）中。为了确定绵羊的分泌途径，在褪黑素分泌的内源性高峰期间，同时采集颈静脉血样和枕大池脑脊液样本。假设绵羊体内褪黑素的分布可以建模为一个时不变线性系统，建立了两个联立方程，其中仅有的两个未知量，即进入血液和进入脑室的输入函数，与通过向颈静脉和侧脑室注射已知量的褪黑素后获得的浓度曲线推导得到的权重函数进行卷积。在频域进行反卷积后评估各自的输入函数。分泌到血液中的褪黑素量比分泌到脑脊液中的量多100倍以上。
