Shaw P F, Kennaway D J, Seamark R F
Department of Obstetrics and Gynaecology, Medical School, University of Adelaide, South Australia.
J Pineal Res. 1989;6(3):201-8. doi: 10.1111/j.1600-079x.1989.tb00416.x.
In this study we examined the cerebrospinal fluid (CSF) for regional differences in the concentration of melatonin. Cerebrospinal fluid samples were collected at hourly intervals from either the lateral ventricle or the cisterna magna of nine Merino ewes and were compared against jugular plasma. The study revealed that the CSF of the cisterna magna and the lateral ventricle had temporal patterns of melatonin that were similar to those found in jugular plasma. However, the concentrations of melatonin within the CSF obtained from the lateral ventricle were one order of magnitude higher than those of the jugular plasma, as verified by gas chromatography and mass spectrometry, while the melatonin concentrations within the CSF obtained from the cisterna magna were comparable to those of the jugular plasma. The data from this study suggest that there may be regional differences in the concentration of melatonin within the CSF and indicate that this medium is an important route of transport for melatonin from the pineal gland to putative target tissues.
在本研究中，我们检测了脑脊液（CSF）中褪黑素浓度的区域差异。从9只美利奴母羊的侧脑室或枕大池每隔一小时采集脑脊液样本，并与颈静脉血浆进行比较。研究表明，枕大池和侧脑室的脑脊液中褪黑素的时间模式与颈静脉血浆中的相似。然而，经气相色谱和质谱验证，从侧脑室获得的脑脊液中褪黑素的浓度比颈静脉血浆中的高一个数量级，而从枕大池获得的脑脊液中褪黑素的浓度与颈静脉血浆中的相当。本研究的数据表明，脑脊液中褪黑素的浓度可能存在区域差异，并表明这种介质是褪黑素从松果体运输到假定靶组织的重要途径。
