Stricker E M
J Comp Physiol Psychol. 1977 Dec;91(6):1220-31. doi: 10.1037/h0078072.
Ligation of the inferior vena cava and administration of isoproterenol have been shown to stimulate renin secretion and to augment water intake in rats. However, the present experiments suggested that the plasma renin activities produced by these treatments do not account for more than 20% of the observed drinking behavior. Direct measurements of arterial blood pressure further indicated that nephrectomized rats go into hypotensive shock after caval ligation or isoproterenol treatment. Drinking was elicited in these hypotensive animals by systemic injection of hypertonic NaCl solution, renin, or Pitressin, or by intracranial injection of angiotensin, but in each case a rapid increase in blood pressure also was observed. Thus, it appears that nephrectomy reduces water intake in these animals by undermining their general capacity to behave rather than by removing a specific dipsogenic stimulus. These and other results suggested that drinking elicited in rats by caval ligation or isoproterenol is not mediated by the renin-angiotensin system.
下腔静脉结扎和给予异丙肾上腺素已被证明可刺激大鼠肾素分泌并增加水摄入量。然而，目前的实验表明，这些处理所产生的血浆肾素活性对所观察到的饮水行为的影响不超过20%。动脉血压的直接测量进一步表明，肾切除大鼠在腔静脉结扎或异丙肾上腺素处理后会进入低血压休克状态。通过全身注射高渗氯化钠溶液、肾素或加压素，或通过颅内注射血管紧张素，可使这些低血压动物产生饮水行为，但在每种情况下，也观察到血压迅速升高。因此，似乎肾切除术通过损害这些动物的一般行为能力而不是通过消除特定的致渴刺激来减少水摄入量。这些以及其他结果表明，腔静脉结扎或异丙肾上腺素在大鼠中引发的饮水行为不是由肾素-血管紧张素系统介导的。
