麻醉犬输注前列腺素E1期间尿激肽释放酶排泄增加及其与利钠和利尿的关系。
Increased urinary kallikrein excretion during prostaglandin E1 infusion in anaesthetized dogs and its relation to natriuresis and diuresis.
作者信息
Mills I H, Obika L F
出版信息
J Physiol. 1977 Dec;273(2):459-74. doi: 10.1113/jphysiol.1977.sp012104.
Abstract
. The effect of intra-arterial prostaglandin E1 (PGE1) infusion on urinary kallikrein, sodium, potassium and water excretion was studied in normal anaesthetized dogs. 2. Infusion of PGE1 caused a dose-related increase in urinary excretion of kallikrein, sodium, potassium and water as well as an increase in renal blood flow (R.B.F.) and a fall in urinary osmolality and renal vascular resistance. 3. The changes occurred in the absence of appreciable changes in inulin clearance (Cin), arterial blood pressure, haematocrit, and plasma sodium and potassium concentrations. 4. The increased urinary kallikrein excretion correlated positively with the natriuresis, diuresis and kaliuresis and the increase in renal blood flow, but negatively with the urinary osmolality and renal vascular resistance. 5. It is concluded that renal kallikrein is involved in the renal response to arterial infusion of PGE1.
摘要
- 研究了动脉内输注前列腺素E1（PGE1）对正常麻醉犬尿激肽释放酶、钠、钾和水排泄的影响。2. 输注PGE1导致尿激肽释放酶、钠、钾和水的排泄呈剂量相关增加，同时肾血流量（R.B.F.）增加，尿渗透压和肾血管阻力下降。3. 这些变化发生时，菊粉清除率（Cin）、动脉血压、血细胞比容以及血浆钠和钾浓度没有明显变化。4. 尿激肽释放酶排泄增加与利钠、利尿、利钾以及肾血流量增加呈正相关，但与尿渗透压和肾血管阻力呈负相关。5. 得出的结论是，肾激肽释放酶参与了肾脏对动脉输注PGE1的反应。
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Increased urinary kallikrein excretion during prostaglandin E1 infusion in anaesthetized dogs and its relation to natriuresis and diuresis.麻醉犬输注前列腺素E1期间尿激肽释放酶排泄增加及其与利钠和利尿的关系。
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