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The effect of hypo-osmolarity upon transepithelial ion transport in cultured renal epithelial layers (MDCK).低渗对培养的肾上皮层（MDCK）跨上皮离子转运的影响。
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Acetylcholine and kinin augmentation of Cl- secretion stimulated by prostaglandin in a canine renal epithelial cell line.前列腺素刺激犬肾上皮细胞系中氯离子分泌时乙酰胆碱和激肽的增强作用。
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本文引用的文献

1
Renal function in conscious rats after indomethacin. Evidence for a tubular action of endogenous prostaglandins.消炎痛作用后清醒大鼠的肾功能。内源性前列腺素肾小管作用的证据。
J Physiol. 1980 Jan;298:371-81. doi: 10.1113/jphysiol.1980.sp013087.
2
Stimulation of Cl- secretion by exogenous ATP in cultured MDCK epithelial monolayers.
Biochim Biophys Acta. 1981 Aug 20;646(2):231-42. doi: 10.1016/0005-2736(81)90329-1.
3
Distribution of prostaglandin E2-sensitive adenylate cyclase along the rat nephron.前列腺素E2敏感性腺苷酸环化酶在大鼠肾单位中的分布。
Prostaglandins. 1981 Mar;21(3):427-38. doi: 10.1016/0090-6980(81)90088-5.
4
Stimulation of sodium and of chloride transport in epithelia by forskolin.福斯高林对上皮细胞中钠和氯转运的刺激作用。
Br J Pharmacol. 1982 May;76(1):33-5. doi: 10.1111/j.1476-5381.1982.tb09187.x.
5
Arachidonic acid metabolism, prostaglandins and the kidney.花生四烯酸代谢、前列腺素与肾脏。
Am J Med. 1982 Feb;72(2):354-74. doi: 10.1016/0002-9343(82)90826-9.
6
Absence of direct effects of prostaglandins on sodium chloride transport in the mammalian nephron.前列腺素对哺乳动物肾单位中氯化钠转运无直接作用。
Kidney Int. 1981 Jun;19(6):797-801. doi: 10.1038/ki.1981.83.
7
Effect of prostaglandins on renal epithelial electrolyte transport.前列腺素对肾上皮电解质转运的影响。
Kidney Int. 1981 Jun;19(6):791-6. doi: 10.1038/ki.1981.82.
8
Identification of two strains of cultured canine renal epithelial cells (MDCK cells) which display entirely different physiological properties.鉴定出两株培养的犬肾上皮细胞（MDCK细胞），它们表现出完全不同的生理特性。
Q J Exp Physiol. 1981 Jan;66(1):61-72. doi: 10.1113/expphysiol.1981.sp002529.
9
Prostaglandin synthesis and renal function in man.人类体内前列腺素的合成与肾功能
J Physiol. 1980 Jan;298:383-96. doi: 10.1113/jphysiol.1980.sp013088.
10
Control of cultured epithelial (MDCK) cell transport function: identification of a beta-adrenoceptor coupled to adenylate cyclase.培养的上皮细胞（MDCK）转运功能的调控：鉴定一种与腺苷酸环化酶偶联的β-肾上腺素能受体。
Q J Exp Physiol. 1984 Apr;69(2):339-53. doi: 10.1113/expphysiol.1984.sp002810.

前列腺素E1和福斯高林在犬肾上皮细胞系中刺激氯化物分泌。

Chloride secretion stimulated by prostaglandin E1 and by forskolin in a canine renal epithelial cell line.

作者信息

Simmons N L

机构信息

Department of Physiological Sciences, Medical School, University of Newcastle upon Tyne.

出版信息

J Physiol. 1991 Jan;432:459-72. doi: 10.1113/jphysiol.1991.sp018394.

DOI:10.1113/jphysiol.1991.sp018394
PMID:1653324
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1181335/
Abstract
  1. The actions of prostaglandins upon ion transport in a renal-derived cultured epithelium (MDCK) have been investigated. 2. Prostaglandin E1 (PGE1) stimulates an inwards short-circuit current (SCC) in voltage-clamped epithelial layers mounted in Ussing chambers. Measurements of transepithelial Cl- fluxes, cation and anion replacement of the bathing media and the use of the Cl- channel blocker 3-nitro-2(3-phenylpropylamino)-benzoic acid (NPPB) are consistent with the PGE1-stimulated inward SCC resulting predominantly from basal to apical Cl- secretion. 3. The response of MDCK epithelia is relatively specific for prostaglandins of the E series. PGE1 is most effective when applied to the basal bathing solutions, though near-maximal stimulation of SCC was possible with 1 microM-PGE1 added to the apical bathing solution. 4. Forskolin addition (10 microM) stimulates an inwards SCC in MDCK epithelia which displays similar characteristics and is of a similar magnitude to that observed with PGE1. In the presence of isobutylmethylzanthine, PGE1 and forskolin are capable of elevating intracellular cyclic AMP accumulation, suggesting that stimulation of inward SCC is mediated via a cyclic AMP-dependent mechanism.
摘要
  1. 已对前列腺素在源自肾脏的培养上皮细胞（MDCK）中对离子转运的作用进行了研究。2. 前列腺素E1（PGE1）可刺激置于尤斯灌流小室中的电压钳制上皮层出现内向短路电流（SCC）。对跨上皮Cl-通量、浴液中阳离子和阴离子的置换以及使用Cl-通道阻滞剂3-硝基-2（3-苯丙基氨基）苯甲酸（NPPB）的测量结果表明，PGE1刺激的内向SCC主要源于从基底到顶端的Cl-分泌。3. MDCK上皮细胞的反应对E系列前列腺素具有相对特异性。将PGE1应用于基底浴液时最为有效，不过在顶端浴液中添加1μM - PGE1也可实现对SCC的近最大刺激。4. 添加福斯高林（10μM）可刺激MDCK上皮细胞出现内向SCC，其表现出与PGE1相似的特征且幅度相近。在存在异丁基甲基黄嘌呤的情况下，PGE1和福斯高林能够提高细胞内环磷酸腺苷（cAMP）的积累，这表明内向SCC的刺激是通过一种依赖于cAMP的机制介导的。