市售假牙清洁剂的潜在生物危害。

Potential biological hazards of commercially available cleansers for dentures.

作者信息

Osterberg R E, Bierbower G W, Seabaugh V M, Porter W K

出版信息

J Toxicol Environ Health. 1977 Dec;3(5-6):969-77. doi: 10.1080/15287397709529631.

Abstract

Thirteen representative denture cleansers were selected from among more than 32 retail products to be tested for potential hazard and toxicity to humans. Products were subjected to toxicological analyses by using the biological tests (acute oral toxicity in rats, eye and skin irritation in rabbits) specified in the Federal Hazardous Substances Act Regulations. All products were eye irritants with ranges from slight to severe. Three produced a primary skin irritation response (one was corrosive), while five of the denture cleansers produced oral LD50 values below 5 g/kg. Furthermore, a provisional upper gastrointestinal irritancy test used in rabbits indicated that eight of the denture cleansers produced upper gastrointestinal irritation, which was, in general, dose-related.

摘要

从32种以上的零售产品中挑选出13种有代表性的假牙清洁剂，对其对人体的潜在危害和毒性进行测试。根据《联邦有害物质法》规定的生物测试（大鼠急性经口毒性、家兔眼和皮肤刺激性）对产品进行毒理学分析。所有产品均有眼部刺激性，程度从轻微到严重不等。三种产品产生了原发性皮肤刺激反应（一种具有腐蚀性），而五种假牙清洁剂的经口半数致死剂量值低于5克/千克。此外，在家兔身上进行的一项临时上消化道刺激性试验表明，八种假牙清洁剂会产生上消化道刺激，一般与剂量有关。