Osterberg R E, Bierbower G W, Hehir R M
J Toxicol Environ Health. 1977 Dec;3(5-6):979-87. doi: 10.1080/15287397709529632.
Tris(2,3-dibromopropyl) phosphate (TRIS) was the most popular flame retardant chemical used in children's sleepwear. Acute toxicological data indicated that TRIS was low in toxicity. Since human exposure to TRIS-treated fabrics could occur for long periods of time, a subchronic study was undertaken to obtain additional information. The dermal application of TRIS (neat) at a dose of 1 ml/kg (2.27 g/kg) to the clipped backs of albino rabbits, once each week for 3 months, resulted in testicular atrophy and chronic interstitial nephritis in males. Females did not show any adverse effects.
